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Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
http://hdl.handle.net/2298/10390
http://hdl.handle.net/2298/103902500821a-7a9b-4d25-b46f-ce9f8f4f8aec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Haraguchi et al 2007.pdf (5.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-01-09 | |||||
| タイトル | ||||||
| タイトル | Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Urinary bladder, External genitalia, Cloaca, Internal urethra, Pelvic urethra, Shh (sonic hedgehog), Gli, PCM (peri-cloacal mesenchyme), Smooth muscle, Exstrophy, Mouse | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Haraguchi, Ryuma
× Haraguchi, Ryuma× Motoyama, Jun× Sasaki, Hiroshi× Satoh, Yoshihiko× Miyagawa, Shinichi× 中潟, 直己× Moon, Anne× 山田, 源 |
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| 別言語の著者 |
原口, 竜摩
× 原口, 竜摩× 宮川, 信一× 佐藤, 義彦× 中瀉, 直己× 山田, 源 |
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| 内容記述 | ||||||
| 内容記述 | The urogenital and reproductive organs, including the external genitalia, bladder and urethra, develop as anatomically aligned organs. Descriptive and experimental embryology suggest that the cloaca, and its derivative, the urogenital sinus, contribute to the formation of these organs. However, it is unknown how the primary tissue lineages in, and adjacent to, the cloaca give rise to the above organs, nor is bladder formation understood. While it is known that sonic hedgehog (Shh) is expressed by the cloacal epithelia, the developmental programs that regulate and coordinate the formation of the urogenital and reproductive organs have not been elucidated. Here we report that Shh mutant embryos display hypoplasia of external genitalia, internal urethra (pelvic urethra) and bladder. The importance of Shh signaling in the development of bladder and external genitalia was confirmed by analyzing a variety of mutant mouse lines with defective hedgehog signaling. By genetically labeling hedgehog-responding tissue lineages adjacent to the cloaca and urogenital sinus, we defined the contribution of these tissues to the bladder and external genitalia. We discovered that development of smooth muscle myosin-positive embryonic bladder mesenchyme requires Shh signaling, and that the bladder mesenchyme and dorsal (upper) external genitalia derive from Shh-responsive peri-cloacal mesenchyme. Thus, the mesenchymal precursors for multiple urogenital structures derive from peri-cloacal mesenchyme and the coordination of urogenital organ formation from these precursors is orchestrated by Shh signals. |
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| 書誌情報 |
Development 巻 134, 号 3, p. 525-533, 発行年 2007-02 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10667805 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1242/dev.02736 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 09501991 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 5584725 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.937 | |||||
| 出版者 | ||||||
| 出版者 | Company of Biologists | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://dev.biologists.org/cgi/content/full/134/3/525 | |||||
