{"created":"2023-06-19T09:10:27.858425+00:00","id":21965,"links":{},"metadata":{"_buckets":{"deposit":"0c370a38-53ff-47df-a054-3c924c0303dc"},"_deposit":{"created_by":1,"id":"21965","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21965"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021965","sets":["407:483:484"]},"author_link":["132733","95108","95111","95106","95122","95120","95107","95119","95105","95118","95121","95104","95109"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"533","bibliographicPageStart":"525","bibliographicVolumeNumber":"134","bibliographic_titles":[{"bibliographic_title":"Development"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"原口, 竜摩"}],"nameIdentifiers":[{"nameIdentifier":"95118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮川, 信一"}],"nameIdentifiers":[{"nameIdentifier":"95119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 義彦"}],"nameIdentifiers":[{"nameIdentifier":"95120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中瀉, 直己"}],"nameIdentifiers":[{"nameIdentifier":"95121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 源"}],"nameIdentifiers":[{"nameIdentifier":"95122","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The urogenital and reproductive organs, including the external genitalia, bladder and urethra, develop as anatomically aligned\norgans. Descriptive and experimental embryology suggest that the cloaca, and its derivative, the urogenital sinus, contribute to the\nformation of these organs. However, it is unknown how the primary tissue lineages in, and adjacent to, the cloaca give rise to the\nabove organs, nor is bladder formation understood. While it is known that sonic hedgehog (Shh) is expressed by the cloacal\nepithelia, the developmental programs that regulate and coordinate the formation of the urogenital and reproductive organs have\nnot been elucidated. Here we report that Shh mutant embryos display hypoplasia of external genitalia, internal urethra (pelvic\nurethra) and bladder. The importance of Shh signaling in the development of bladder and external genitalia was confirmed by\nanalyzing a variety of mutant mouse lines with defective hedgehog signaling. By genetically labeling hedgehog-responding tissue\nlineages adjacent to the cloaca and urogenital sinus, we defined the contribution of these tissues to the bladder and external\ngenitalia. We discovered that development of smooth muscle myosin-positive embryonic bladder mesenchyme requires Shh\nsignaling, and that the bladder mesenchyme and dorsal (upper) external genitalia derive from Shh-responsive peri-cloacal\nmesenchyme. Thus, the mesenchymal precursors for multiple urogenital structures derive from peri-cloacal mesenchyme and the\ncoordination of urogenital organ formation from these precursors is orchestrated by Shh signals.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://dev.biologists.org/cgi/content/full/134/3/525","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Company of Biologists"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1242/dev.02736","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"09501991"}]}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10667805","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.937","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"5584725 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Haraguchi, Ryuma"}],"nameIdentifiers":[{"nameIdentifier":"95105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motoyama, Jun"}],"nameIdentifiers":[{"nameIdentifier":"95106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"95107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satoh, Yoshihiko"}],"nameIdentifiers":[{"nameIdentifier":"95108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyagawa, Shinichi"}],"nameIdentifiers":[{"nameIdentifier":"95109","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中潟, 直己","creatorNameLang":"ja"},{"creatorName":"ナカガタ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakagata, Naomi","creatorNameLang":"en"}],"familyNames":[{"familyName":"中潟","familyNameLang":"ja"},{"familyName":"ナカガタ","familyNameLang":"ja-Kana"},{"familyName":"Nakagata","familyNameLang":"en"}],"givenNames":[{"givenName":"直己","givenNameLang":"ja"},{"givenName":"ナオミ","givenNameLang":"ja-Kana"},{"givenName":"Naomi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"132733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moon, Anne"}],"nameIdentifiers":[{"nameIdentifier":"95111","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山田, 源","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ゲン","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Gen","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"源","givenNameLang":"ja"},{"givenName":"ゲン","givenNameLang":"ja-Kana"},{"givenName":"Gen","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Haraguchi et al 2007.pdf","filesize":[{"value":"5.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Haraguchi et al 2007.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21965/files/Haraguchi et al 2007.pdf"},"version_id":"44c5b42d-8086-496f-97c4-ef0c49180fd9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Urinary bladder","subitem_subject_scheme":"Other"},{"subitem_subject":"External genitalia","subitem_subject_scheme":"Other"},{"subitem_subject":"Cloaca","subitem_subject_scheme":"Other"},{"subitem_subject":"Internal urethra","subitem_subject_scheme":"Other"},{"subitem_subject":"Pelvic urethra","subitem_subject_scheme":"Other"},{"subitem_subject":"Shh (sonic hedgehog)","subitem_subject_scheme":"Other"},{"subitem_subject":"Gli","subitem_subject_scheme":"Other"},{"subitem_subject":"PCM (peri-cloacal mesenchyme)","subitem_subject_scheme":"Other"},{"subitem_subject":"Smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"Exstrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling"}]},"item_type_id":"16","owner":"1","path":["484"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-09"},"publish_date":"2009-01-09","publish_status":"0","recid":"21965","relation_version_is_last":true,"title":["Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-08T06:33:44.530947+00:00"}