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Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
http://hdl.handle.net/2298/10392
http://hdl.handle.net/2298/103921687bc55-3667-49f0-823d-fc274be1f5f6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Haraguchi_2000.pdf (319.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-01-09 | |||||
| タイトル | ||||||
| タイトル | Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | FGF8, FGF10, Msx1, Hox, Bmp4, Genital tubercle, Clitoris, Penis, Limb, AER, Epithelial-mesenchymal interaction, Gene knockout mouse | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Haraguchi, Ryuma
× Haraguchi, Ryuma× Suzuki, K.× Murakami, R.× Sakai, M.× Kamikawa, M.× Kengaku, M.× Sekine, K.× Kawano, H.× Kato, S.× Ueno, N.× 山田, 源 |
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| 内容記述 | ||||||
| 内容記述 | The molecular mechanisms underlying the development of the external genitalia in mammals have been very little examined. Recent gene knockout studies have suggested that the developmental processes of its anlage, the genital tubercle (GT), have much in common with those of limb buds. The Fgf genes have been postulated as regulating several downstream genes during organogenesis. Fgf8 was expressed in the distal urethral plate epithelium of the genital tubercle (GT) together with other markers such as the Msx1, Fgf10, Hoxd13 and Bmp4 expressed in the mesenchyme. To analyze the role of the FGF system during GT formation, an in vitro organ culture system was utilized. It is suggested that the distal urethral plate epithelium of GT, the Fgf8-expressing region, regulates the outgrowth of GT. Ectopic application of FGF8 beads to the murine GT induced mesenchymal gene expression, and also promoted the outgrowth of the GT. Experiments utilizing anti-FGF neutralizing antibody suggested a growth-promoting role for FGF protein(s) in GT outgrowth. In contrast, despite its vital role during limb-bud formation, Fgf10 appears not to be primarily essential for initial outgrowth of GT, as extrapolated from Fgf10(−/−) GTs. However, the abnormal external genitalia development of Fgf10(−/−) perinatal mice suggested the importance of Fgf10 in the development of the glans penis and the glans clitoridis. These results suggest that the FGF system is a key element in orchestrating GT development. | |||||
| 書誌情報 |
Development 巻 127, 号 11, p. 2471-2479, 発行年 2000-06 |
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10667805 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.1242/dev.127.11.2471 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 09501991 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 319768 bytes | ||||||
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| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.937 | |||||
| 出版者 | ||||||
| 出版者 | Company of Biologists | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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