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Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells
http://hdl.handle.net/2298/10909
http://hdl.handle.net/2298/10909c4307db9-8a4a-41b3-a722-f4e7efe7d7ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Okada et al.pdf (524.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-02-23 | |||||
| タイトル | ||||||
| タイトル | Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | hematopoietic stem cell, immunodeficient mice, CD34, transplantation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
岡田, 誠治
× 岡田, 誠治× Harada, Hideki× Ito, Takaaki× 齋藤, 孝× Suzu, Shinya |
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| 別言語の著者 |
岡田, 誠治
× 岡田, 誠治× 原田, 英樹× 伊藤, 隆明× 斉藤, 隆× 鈴, 伸也 |
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| 内容記述 | ||||||
| 内容記述 | An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3null mouse, for the human immune system's development. Newborn mice transplanted with human cord blood CD34+ cells intrahepatically, developed human T and B cells, and myeloid and plasmacytoid dendritic cells. The T and B cells had a naïve to memory phenotype, and included plasma cells. The human acquired immune system can be reconstituted from CD34+ cells in NOD/SCID/JAK3null mice. This model is a powerful tool for the study of human immunity. | |||||
| 書誌情報 |
International Journal of Hematology 巻 88, 号 5, p. 476-482, 発行年 2008-12 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10797094 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s12185-008-0215-z | |||||
| 権利 | ||||||
| 権利情報 | © 2008 The Japanese Society of Hematology. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 09255710 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 524115 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.878 | |||||
| 出版者 | ||||||
| 出版者 | 日本血液学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.jshem.or.jp/journal/ | |||||
