{"created":"2023-06-19T09:10:43.751449+00:00","id":22261,"links":{},"metadata":{"_buckets":{"deposit":"7e14c3c2-5cfc-4ff0-bfd4-06e0ce85ab57"},"_deposit":{"created_by":127,"id":"22261","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"22261"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022261","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2008-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"上皮型Naチャネル（ENaC）は糸球体で濾過されたNaの最終的な排泄量を調節する重要なチャネルである。プロスタシンはENaCを活性化する重要な調節因子である。これまでの研究によりプロスタシンが生体において高血圧、Na代謝に関与している可能性が示唆されている。プロスタシンを中心としたNa再吸収、血圧調節の分子基盤が解明されれば新規作用機序による降圧薬や利尿薬の開発につながる可能性がある。そこでプロスタシンの内因性阻害物質として報告されたprptease nexin-1(PN-1)とプロスタシンとの相互作用によるENaC活性の調節について検討を行った。さらにNOによるNa利尿作用におけるプロスタシンの役割についても検討を行った。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1637号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1637号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"脇田, 直樹","creatorNameLang":"ja"},{"creatorName":"ワキタ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Wakida, Naoki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1637.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1637.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22261/files/22-1637.pdf"},"version_id":"d1a7b65a-a1c6-41b7-8835-465b3716c97c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"上皮型Naチャネル(ENaC)","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"prptease nexin-1(PN-1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NO","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Na利尿作用","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"プロスタシンを中心としたNa再吸収、血圧調節の分子基盤の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロスタシンを中心としたNa再吸収、血圧調節の分子基盤の解明","subitem_title_language":"ja"},{"subitem_title":"プロスタシン オ チュウシン トシタ Na サイキュウシュウ ケツアツ チョウセツ ノ ブンシ キバン ノ カイメイ","subitem_title_language":"ja-Kana"},{"subitem_title":"The molecular basis of Na reabsorption and blood pressure control by serine protease prostasin","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-08-12"},"publish_date":"2014-08-12","publish_status":"0","recid":"22261","relation_version_is_last":true,"title":["プロスタシンを中心としたNa再吸収、血圧調節の分子基盤の解明"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:28:49.806931+00:00"}