{"created":"2023-06-19T09:10:44.026497+00:00","id":22267,"links":{},"metadata":{"_buckets":{"deposit":"323934ab-ab41-4ca5-b7e3-7c345b4ec9d4"},"_deposit":{"created_by":1,"id":"22267","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22267"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022267","sets":["343:347:348:349"]},"author_link":["96825","96826","96824"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of HIV-1 specific cytotoxic CD8+T lymphocyte restricted by HLA alleles associated with slow progression to AIDS"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"エイズ ハッショウ チエン ト ソウカン スル HLA コウゲン ニ コウソク サレル HIV-1 トクイテキ サイボウ ショウガイセイ CD8+T サイボウ ノ カイセキ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawashima, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"96826","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"text/plain","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"日本人にみられる3つのHLA-A26のうち、HIV-1特異的なCTLエピトープが報告されていないHLA-A*2602、-A*2603に提示されるエピトープの同定を行い、3つのHLA-A26アレルに拘束されるエピトープに特異的なCTLの詳細な解析を行った。HLA-B*5101では、3つのエピトープ（Gag327-9、Pol283-8、Pol743-9）特異的なCTLがHIV-1感染者で高頻度に検出され、これらのエピトープ特異的CTLのAIDS発症遅延への関与が示唆された。そこで、この3つのエピトープ特異的CTLがHLA-B*5101を持つ長期未発症者(LTNP)でHIV-1の増殖抑制に働いているのかを明らかにするために解析を行った。AIDS発症遅延と相関するHLAに拘束されるCTLの解析によって、これらのCTLが生体内でのウイルス増殖抑制にどのように働いているのかを明らかにすることを目的とした。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"3462766 bytes"},{"subitem_text_value":"60979 bytes"},{"subitem_text_value":"88070 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1643号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川島, 夕佳"}],"nameIdentifiers":[{"nameIdentifier":"96824","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1643.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1643.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22267/files/22-1643.pdf"},"version_id":"dfb7aa30-c075-44ca-87dd-cf018ee8a97b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"細胞傷害性T細胞(CTL)","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-A26アレル","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-B*5101","subitem_subject_scheme":"Other"},{"subitem_subject":"LTNP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"エイズ発症遅延と相関するHLA抗原に拘束されるHIV-1特異的細胞傷害性CD8+T細胞の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エイズ発症遅延と相関するHLA抗原に拘束されるHIV-1特異的細胞傷害性CD8+T細胞の解析"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-12"},"publish_date":"2014-08-12","publish_status":"0","recid":"22267","relation_version_is_last":true,"title":["エイズ発症遅延と相関するHLA抗原に拘束されるHIV-1特異的細胞傷害性CD8+T細胞の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:54:56.520275+00:00"}