@misc{oai:kumadai.repo.nii.ac.jp:00022268,
 author = {Monde, Kazuaki and 門出 和精},
 month = {Mar},
 note = {application/pdf, application/pdf, text/plain, 学位論文(Thesis), Entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells requires sequential interactions of the envelope glycoprotein gp120 with the receptor CD4 and the coreceptor CCR5. I investigated replication of 45 R5 viral clones derived from the HIV-IJR-FLan library carrying 0-10 random amino acid substitutions in the gp120 V3 loop, and found that 6.7% (3/45) of the viruses revealed MO-fold replication suppression in PM1/CCR5 cells expressing high levels of CCR5 compared to PM1 cells expressing low levels of CCR5., 本研究ではCCR5と直接相互作用するgp120のV3loopに0-10個のアミノ酸置換の組み合わせを持つHIV-1 JR-FLanライブラリーを使い、 V3領域の配列が異なる45種
類のR5 HIV-1クローンを分離し、CCR5低発現CD4＋T細胞PM1と高発現細胞PM1/CCR5でその複製能を比較した。},
 title = {ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下},
 year = {2008}
}