{"created":"2023-06-19T09:10:44.070774+00:00","id":22268,"links":{},"metadata":{"_buckets":{"deposit":"ce19203e-4895-4cb9-995a-47e81de4e424"},"_deposit":{"created_by":1,"id":"22268","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22268"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022268","sets":["343:347:348:349"]},"author_link":["96828","96829","96827"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Impairment of R5 HIV-1 infectivity due to virion incorporated CCR5"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ウイルス リュウシ エノ CCR5 ノ トリコミ ニ ヨル R5 HIV-1 ノ カンセンセイ テイカ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Monde, Kazuaki"}],"nameIdentifiers":[{"nameIdentifier":"96829","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"text/plain","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells requires sequential interactions of the envelope glycoprotein gp120 with the receptor CD4 and the coreceptor CCR5. I investigated replication of 45 R5 viral clones derived from the HIV-IJR-FLan library carrying 0-10 random amino acid substitutions in the gp120 V3 loop, and found that 6.7% (3/45) of the viruses revealed MO-fold replication suppression in PM1/CCR5 cells expressing high levels of CCR5 compared to PM1 cells expressing low levels of CCR5.","subitem_description_type":"Other"},{"subitem_description":"本研究ではCCR5と直接相互作用するgp120のV3loopに0-10個のアミノ酸置換の組み合わせを持つHIV-1 JR-FLanライブラリーを使い、 V3領域の配列が異なる45種\n類のR5 HIV-1クローンを分離し、CCR5低発現CD4＋T細胞PM1と高発現細胞PM1/CCR5でその複製能を比較した。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"2244376 bytes"},{"subitem_text_value":"60936 bytes"},{"subitem_text_value":"72278 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1644号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"門出 和精"}],"nameIdentifiers":[{"nameIdentifier":"96827","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1644.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1644.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22268/files/22-1644.pdf"},"version_id":"4b767a9a-37fb-4dfd-aae2-e177a49e67c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"R5 HIV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"エンベロープタンパク質(Env)","subitem_subject_scheme":"Other"},{"subitem_subject":"gp120","subitem_subject_scheme":"Other"},{"subitem_subject":"CD4","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1JR-FLanライブラリー","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1V3L#08","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-12"},"publish_date":"2014-08-12","publish_status":"0","recid":"22268","relation_version_is_last":true,"title":["ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:54:55.677602+00:00"}