{"created":"2023-06-19T09:10:45.304994+00:00","id":22296,"links":{},"metadata":{"_buckets":{"deposit":"b62111cb-ea12-48df-9f11-265bef253bdb"},"_deposit":{"created_by":1,"id":"22296","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22296"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022296","sets":["343:344:345:346"]},"author_link":["96913","96911","96912"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Forensic toxicology of chloroquine, an anti-malarial agent"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウ マラリアヤク クロロキン ノ ホウチュウドクガクテキ ケンキュウ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-11","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koreeda, Ako"}],"nameIdentifiers":[{"nameIdentifier":"96913","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"text/plain","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本稿では、発展途上国における法中毒学に対して学術的支援を行う目的から、CQの法中毒学的研究として以下の3つの研究を行った。まず、急性CQ中毒死事例における組織中CQ濃度の定量（第VI章）においては、簡便な高速液体クロマトグラフィー（HPLC）によるCQ分析方法を考案し、その方法を用いてタンザニアでの急性CQ中毒死事例におけるCQの体組織分布を調べた（Yonemitsu et al., 2002; Yonemitsu et al., 2005）。また、急性CQ中毒マウスにおけるCQの組織内分布（第VII章）においては、CQに対するポリクローナル抗体を作製し、抗CQポリクローナル抗体を用いた免疫組織染色法によって急性CQ中毒モデルマウスの組織中におけるCQの分布状態を検索し、これをCQの急性毒性機序の理解を深める一助となる様に検討を行った（Koreeda et al., 2007a）。さらに、抗CQモノクローナル抗体（MAC）を用いた試料中CQ濃度の簡易半定量システムの開発（第VIII章）では、CQの簡易検出法を開発することを目的に、 CQに対するモノクローナル抗体を作製し、これを用いた半定量法を考案してその有用性について検討した。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.15","subitem_subject_scheme":"NDC"},{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"60856 bytes"},{"subitem_text_value":"2590565 bytes"},{"subitem_text_value":"56597 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"乙博医第913号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"是枝, 亜子"}],"nameIdentifiers":[{"nameIdentifier":"96911","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"32-0913.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"32-0913.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22296/files/32-0913.pdf"},"version_id":"73246460-1e6b-4ab4-ac58-cb5f6ebafd48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"急性クロロキン","subitem_subject_scheme":"Other"},{"subitem_subject":"抗CQポリクローナル 抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"抗CQモノクローナル抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"ハイブリドーマ","subitem_subject_scheme":"Other"},{"subitem_subject":"CQ","subitem_subject_scheme":"Other"},{"subitem_subject":"PAC","subitem_subject_scheme":"Other"},{"subitem_subject":"MAC","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"抗マラリア薬クロロキンの法中毒学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗マラリア薬クロロキンの法中毒学的研究"}]},"item_type_id":"14","owner":"1","path":["346"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-12"},"publish_date":"2014-08-12","publish_status":"0","recid":"22296","relation_version_is_last":true,"title":["抗マラリア薬クロロキンの法中毒学的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:54:26.899874+00:00"}