{"created":"2023-06-19T09:10:51.044007+00:00","id":22407,"links":{},"metadata":{"_buckets":{"deposit":"6a44fa68-a906-4a8b-b268-536e0817a40b"},"_deposit":{"created_by":1,"id":"22407","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22407"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022407","sets":["413:443"]},"author_link":["97413","93163"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"8","bibliographicPageStart":"3","bibliographicVolumeNumber":"147","bibliographic_titles":[{"bibliographic_title":"Autonomic neuroscience: basic & clinical"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Indo, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"97413","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and maintenance of sensory and sympathetic neurons. Congenital insensitivity to pain with anhidrosis (CIPA) is a genetic disorder due to loss-of-function mutations in the NTRK1 (also known as TRKA) gene encoding TrkA, a receptor tyrosine kinase for NGF. Patients with CIPA provide us a rare opportunity to explore the developmental and physiological function of the NGF-dependent neurons in behavior, cognitive, and mental activities that are not available in animal studies. Here, I discuss the significance of findings that patients with CIPA lack NGF-dependent neurons, including interoceptive polymodal receptors, sympathetic postganglionic neurons, and probably several types of neurons in the brain. They also exhibit characteristic emotional behavior or problems. Together, the NGF-TrkA system is essential for the establishment of a neural network for interoception and homeostasis that may underlie 'gut feelings'. Thus, NGF-dependent neurons play a crucial role in emotional experiences and decision-making processes. Prospective studies focused on these neurons might provide further insights into the neural basis of human emotion and feeling.","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.autneu.2009.01.008","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"15660702"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Elsevier B.V."}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11470577","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"172471 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Indo, Yasuhiro","creatorNameLang":"en"},{"creatorName":"犬童, 康弘","creatorNameLang":"ja"},{"creatorName":"インドウ, ヤスヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Indo","familyNameLang":"en"},{"familyName":"犬童","familyNameLang":"ja"},{"familyName":"インドウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"},{"givenName":"康弘","givenNameLang":"ja"},{"givenName":"ヤスヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"93163","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"AN-09YI.pdf","filesize":[{"value":"172.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN-09YI.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22407/files/AN-09YI.pdf"},"version_id":"a312f93f-4e60-47bc-90d2-f154263570ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nerve growth factor (NGF)","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptor tyrosine kinase for NGF","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ型神経成長因子受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"TrkA protein","subitem_subject_scheme":"Other"},{"subitem_subject":"TrkA タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 gene","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA gene","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"Congenital insensitivity to pain with anhidrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"先天性無痛無汗症","subitem_subject_scheme":"Other"},{"subitem_subject":"Interoception","subitem_subject_scheme":"Other"},{"subitem_subject":"内感覚","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymodal receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリモーダル受容器","subitem_subject_scheme":"Other"},{"subitem_subject":"Sympathetic neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"交感神経ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"Basal forebrain cholinergic neuron","subitem_subject_scheme":"Other"},{"subitem_subject":"前脳基底野コリン作動性ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"Emotion","subitem_subject_scheme":"Other"},{"subitem_subject":"情動","subitem_subject_scheme":"Other"},{"subitem_subject":"Pain","subitem_subject_scheme":"Other"},{"subitem_subject":"痛み","subitem_subject_scheme":"Other"},{"subitem_subject":"疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeostasis","subitem_subject_scheme":"Other"},{"subitem_subject":"恒常性","subitem_subject_scheme":"Other"},{"subitem_subject":"Hereditary sensory and autonomic neuropathy type IV","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性感覚自律神経性ニュー ロパシー IV 型","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-30"},"publish_date":"2009-04-30","publish_status":"0","recid":"22407","relation_version_is_last":true,"title":["Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-08-24T02:45:38.956920+00:00"}