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Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling
http://hdl.handle.net/2298/11529
http://hdl.handle.net/2298/115296adcdd04-18e8-4043-984a-48593ad4cda2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
136_367-372.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-05-14 | |||||
| タイトル | ||||||
| タイトル | Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Skin, Hair follicle (HF), Wnt, β-catenin, Bmp, Shh, Cell fate | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
鈴木, 堅太郎
× 鈴木, 堅太郎× Yamaguchi, Yuji× Villacorte, Mylah× 三原, 健一郎× Akiyama, Masashi× Shimizu, Hitoshi× Taketo, M. Makoto× 中潟, 直己× Tsukiyama, Tadasuke× Yamaguchi, Terry P.× Birchmeier, Walter× Kato, Shigeaki× 山田, 源 |
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| 別言語の著者 |
鈴木, 堅太郎
× 鈴木, 堅太郎× 三原, 健一郎× 中瀉, 直己× 山田, 源 |
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| 内容記述 | ||||||
| 内容記述 | β-catenin signaling is one of the key factors regulating the fate of hair follicles (HFs). To elucidate the regulatory mechanism of embryonic HF fate determination during epidermal development/differentiation, we analyzed conditional mutant mice with keratinocytes expressing constitutively active β-catenin (K5-Cre Catnb(ex3)fl/+). The mutant mice developed scaly skin with a thickened epidermis and showed impaired epidermal stratification. The hair shaft keratins were broadly expressed in the epidermis but there was no expression of the terminal differentiation markers K1 and loricrin. Hair placode markers (Bmp2 and Shh) and follicular dermal condensate markers (noggin, patched 1 and Pdgfra) were expressed throughout the epidermis and the upper dermis, respectively. These results indicate that the embryonic epidermal keratinocytes have switched extensively to the HF fate. A series of genetic studies demonstrated that the epidermal switching to HF fate was suppressed by introducing the conditional mutation K5-Cre Catnb(ex3)fl/+Shhfl/- (with additional mutation of Shh signaling) or K5-Cre Catnb(ex3)fl/+BmprIAfl/fl (with additional mutation of Bmp signaling). These results demonstrate that Wnt/β-catenin signaling relayed through Shh and Bmp signals is the principal regulatory mechanism underlying the HF cell fate change. Assessment of Bmp2 promoter activities suggested a putative regulation by β-catenin signaling relayed by Shh signaling towards Bmp2. We also found that Shh protein expression was increased and expanded in the epidermis of K5-Cre Catnb(ex3)fl/+BmprIAfl/fl mice. These results indicate the presence of growth factor signal cross-talk involving β-catenin signaling, which regulates the HF fate. | |||||
| 書誌情報 |
Development 巻 136, 号 3, p. 367-372, 発行年 2009-03 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10667805 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1242/dev.021295 | |||||
| 権利 | ||||||
| 権利情報 | Company of Biologists | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 09501991 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 1454722 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.937 | |||||
| 出版者 | ||||||
| 出版者 | Company of Biologists | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://dev.biologists.org/cgi/content/full/136/3/367 | |||||
