@article{oai:kumadai.repo.nii.ac.jp:00022635,
 author = {濱田, 哲暢 and Hamada, Akinobu and Sanematsu, Emiko and 齋藤, 秀之 and Saito, Hideyuki and 佐々木, 治一郎 and Sasaki, Jiichiro and 前田, 由紀子 and Maeda, Yukiko and 濱田, 哲暢 and Hamada, Akinobu and Sanematsu, Emiko and 佐々木, 治一郎 and Sasaki, Jiichiro and Yokoo, Koji and Hira, Asumi and Saito, Hideyuki},
 journal = {Cancer Chemotherapy and Pharmacology},
 month = {Aug},
 note = {application/pdf, 論文(Article), PURPOSE: This study examined the pharmacokinetics of irinotecan (CPT-11), active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), SN-38 glucuronide (SN-38G) amrubicin (AMR), and active metabolite amrubicinol (AMR-OH) after intravenous administration of this combination therapy in rats. METHODS: Male Sprague-Dawley rats were treated with 10 mg/kg CPT-11 with 10 mg/kg AMR. AMR, AMR-OH, CPT-11, SN-38 and SN-38G were measured in plasma, bile, and tissues using high-performance liquid chromatography. RESULTS: Co-administration of CPT-11 resulted in a significant decrease in plasma concentrations and area under the curves (AUC) of AMR-OH compared with treatment with AMR alone. On the other hand, co-administration of AMR resulted in a slight increase in the initial plasma concentration of SN-38; however, there were no differences in AUC values in CPT-11 and SN-38. The cumulative biliary excretion curves of AMR, CPT-11, and their active metabolites were not changed. CPT-11 inhibited the conversion of AMR to AMR-OH in rat cytosolic fractions. CONCLUSIONS: CPT-11 did not affect the pharmacokinetic of AMR but decreased the plasma concentration of AMR-OH and might affect the formation of AMR-OH from AMR in hepatocytes., http://www.springerlink.com/content/t57238162t5740n8/fulltext.html},
 pages = {953--959},
 title = {Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats},
 volume = {65},
 year = {2009},
 yomi = {ハマダ, アキノブ and 實松, 絵美子 and サネマツ, エミコ and サイトウ, ヒデユキ and ササキ, ジイチロウ and マエダ, ユキコ and ハマダ, アキノブ and 實松, 絵美子 and サネマツ, エミコ and ササキ, ジイチロウ}
}