{"created":"2023-06-19T09:11:01.564902+00:00","id":22635,"links":{},"metadata":{"_buckets":{"deposit":"c0e4e86a-6d10-4aa1-8735-adbcf279055a"},"_deposit":{"created_by":1,"id":"22635","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22635"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022635","sets":["415:416"]},"author_link":["98308","98296","98307","98295","98305","98297","98306","158098"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08-21","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"959","bibliographicPageStart":"953","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Cancer Chemotherapy and Pharmacology"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱田, 哲暢","creatorNameLang":"ja"},{"creatorName":"ハマダ, アキノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Akinobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"},{"familyName":"Hamada","familyNameLang":"en"}],"givenNames":[{"givenName":"哲暢","givenNameLang":"ja"},{"givenName":"アキノブ","givenNameLang":"ja-Kana"},{"givenName":"Akinobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98305","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"實松, 絵美子","creatorNameLang":""},{"creatorName":"サネマツ, エミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sanematsu, Emiko","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"實松","familyNameLang":""},{"familyName":"サネマツ","familyNameLang":"ja-Kana"},{"familyName":"Sanematsu","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"絵美子","givenNameLang":""},{"givenName":"エミコ","givenNameLang":"ja-Kana"},{"givenName":"Emiko","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"98306","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"齋藤, 秀之","creatorNameLang":"ja"},{"creatorName":"サイトウ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Hideyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"齋藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"},{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"秀之","givenNameLang":"ja"},{"givenName":"ヒデユキ","givenNameLang":"ja-Kana"},{"givenName":"Hideyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98307","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"佐々木, 治一郎","creatorNameLang":"ja"},{"creatorName":"ササキ, ジイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Jiichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐々木","familyNameLang":"ja"},{"familyName":"ササキ","familyNameLang":"ja-Kana"},{"familyName":"Sasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"治一郎","givenNameLang":"ja"},{"givenName":"ジイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Jiichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98308","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"PURPOSE: This study examined the pharmacokinetics of irinotecan (CPT-11), active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), SN-38 glucuronide (SN-38G) amrubicin (AMR), and active metabolite amrubicinol (AMR-OH) after intravenous administration of this combination therapy in rats. METHODS: Male Sprague-Dawley rats were treated with 10 mg/kg CPT-11 with 10 mg/kg AMR. AMR, AMR-OH, CPT-11, SN-38 and SN-38G were measured in plasma, bile, and tissues using high-performance liquid chromatography. RESULTS: Co-administration of CPT-11 resulted in a significant decrease in plasma concentrations and area under the curves (AUC) of AMR-OH compared with treatment with AMR alone. On the other hand, co-administration of AMR resulted in a slight increase in the initial plasma concentration of SN-38; however, there were no differences in AUC values in CPT-11 and SN-38. The cumulative biliary excretion curves of AMR, CPT-11, and their active metabolites were not changed. CPT-11 inhibited the conversion of AMR to AMR-OH in rat cytosolic fractions. CONCLUSIONS: CPT-11 did not affect the pharmacokinetic of AMR but decreased the plasma concentration of AMR-OH and might affect the formation of AMR-OH from AMR in hepatocytes.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.springerlink.com/content/t57238162t5740n8/fulltext.html","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Berlin"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00280-009-1102-x","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"03445704"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer-Verlag 2009"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"248167 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal 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rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-26T02:22:32.239197+00:00"}