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Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer
http://hdl.handle.net/2298/15510
http://hdl.handle.net/2298/155105cbcf003-8dba-41dc-b493-86d008d3f3a4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TDM-YOKOO_r.pdf (139.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-07-26 | |||||
| タイトル | ||||||
| タイトル | Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Drug interaction, Irinotecan, SN-38, S-1, Pharmacokinetics | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Yokoo, Koji
× Yokoo, Koji× 濱田, 哲暢× Tazoe, Kensuke× Sasaki, Yutaka× Saito, Hideyuki |
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| 別言語の著者 |
横尾, 浩司
× 横尾, 浩司× 濱田, 哲暢× 佐々木, 裕× 齋藤, 秀之 |
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| 内容記述 | ||||||
| 内容記述 | Previous studies have assessed the efficacy and safety of combined treatment with irinotecan (7-ethyl-10-[4-[1-piperidino]-1-piperidino]carbonyloxycamptothecin, CPT-11) and S-1, containing tegafur, a prodrug of 5-fluorouracil, in the treatment of colorectal and gastric cancer. The objective of this study was to describe the interaction between CPT-11 and S-1 in 4 patients with colorectal cancer. Coadministration of S-1 changed the pharmacokinetic behavior of CPT-11 and its metabolites. In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1. For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively. A markedly difference in drug interaction among individual patients was observed. We conclude that the plasma concentration of SN-38 was decreased by oral administration of S-1 in patients with colorectal cancer. This observation might be important for clinical decisions regarding combination therapy. | |||||
| 書誌情報 |
Therapeutic Drug Monitoring 巻 31, 号 3, p. 400-403, 発行年 2009-06 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1097/FTD.0b013e31819c67e5 | |||||
| 権利 | ||||||
| 権利情報 | © 2009 by Lippincott Williams & Wilkins. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 01634356 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 139076 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.65 | |||||
| 出版者 | ||||||
| 出版者 | Lippincott, Williams & Wilkins | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://journals.lww.com/drug-monitoring/Abstract/2009/06000/Effects_of_Oral_Administration_of_S_1_on_the.14.aspx | |||||
