{"created":"2023-06-19T09:11:01.653031+00:00","id":22637,"links":{},"metadata":{"_buckets":{"deposit":"6a5d186b-55b4-4bcd-8a4e-9b7670f24137"},"_deposit":{"created_by":1,"id":"22637","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22637"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022637","sets":["415:416"]},"author_link":["98338","98327","98329","98330","98305","98337","98336","98339","98331"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"403","bibliographicPageStart":"400","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Therapeutic Drug Monitoring"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横尾, 浩司"}],"nameIdentifiers":[{"nameIdentifier":"98336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱田, 哲暢"}],"nameIdentifiers":[{"nameIdentifier":"98337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 裕"}],"nameIdentifiers":[{"nameIdentifier":"98338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 秀之"}],"nameIdentifiers":[{"nameIdentifier":"98339","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Previous studies have assessed the efficacy and safety of combined treatment with irinotecan (7-ethyl-10-[4-[1-piperidino]-1-piperidino]carbonyloxycamptothecin, CPT-11) and S-1, containing tegafur, a prodrug of 5-fluorouracil, in the treatment of colorectal and gastric cancer. The objective of this study was to describe the interaction between CPT-11 and S-1 in 4 patients with colorectal cancer. Coadministration of S-1 changed the pharmacokinetic behavior of CPT-11 and its metabolites. In particular, maximum plasma concentration (Cmax) and area under the plasma concentration curve (AUC) of 7-ethyl-10-hydroxycampothecin (SN-38) was markedly decreased by coadministration of S-1. For SN-38, the median ratio of Cmax and AUC with S-1 to those without S-1 was median 0.34 (range 0.24-0.78) and 0.56 (range 0.23-0.68), respectively. A markedly difference in drug interaction among individual patients was observed. We conclude that the plasma concentration of SN-38 was decreased by oral administration of S-1 in patients with colorectal cancer. This observation might be important for clinical decisions regarding combination therapy.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://journals.lww.com/drug-monitoring/Abstract/2009/06000/Effects_of_Oral_Administration_of_S_1_on_the.14.aspx","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott, Williams & Wilkins"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/FTD.0b013e31819c67e5","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"01634356"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2009 by Lippincott Williams & Wilkins."}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"},{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"},{"subitem_subject":"491.65","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"139076 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal 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アキノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Akinobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"},{"familyName":"Hamada","familyNameLang":"en"}],"givenNames":[{"givenName":"哲暢","givenNameLang":"ja"},{"givenName":"アキノブ","givenNameLang":"ja-Kana"},{"givenName":"Akinobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tazoe, Kensuke"}],"nameIdentifiers":[{"nameIdentifier":"98329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"98330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"98331","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"TDM-YOKOO_r.pdf","filesize":[{"value":"139.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TDM-YOKOO_r.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22637/files/TDM-YOKOO_r.pdf"},"version_id":"a1b8926a-cff1-493f-80e2-ca87da33ae51"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Drug interaction","subitem_subject_scheme":"Other"},{"subitem_subject":"Irinotecan","subitem_subject_scheme":"Other"},{"subitem_subject":"SN-38","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmacokinetics","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-26"},"publish_date":"2010-07-26","publish_status":"0","recid":"22637","relation_version_is_last":true,"title":["Effects of oral administration of S-1 on the pharmacokinetics of SN-38, irinotecan active metabolite, in patients with advanced colorectal cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-14T07:09:01.796765+00:00"}