{"created":"2023-06-19T09:11:01.697749+00:00","id":22638,"links":{},"metadata":{"_buckets":{"deposit":"547dbc2a-7a4c-44f2-8d11-601cfabe6649"},"_deposit":{"created_by":1,"id":"22638","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22638"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022638","sets":["415:416"]},"author_link":["98307","98305","166457","166453","166452","166451","166454","166456","166449","166455"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"648","bibliographicPageStart":"642","bibliographicVolumeNumber":"89","bibliographic_titles":[{"bibliographic_title":"International Journal of Hematology"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The standard dose of imatinib for the treatment of chronic-phase chronic myeloid leukemia (CML) is 400 mg/day. Some patients receive reduced doses of imatinib because of serious adverse effects. Recently, the effective plasma threshold for trough imatinib levels was demonstrated to be 1,002 ng/mL. In this study, we evaluated the association of an imatinib dose with trough plasma concentrations and clinical outcomes in 31 patients with chronic-phase CML who were treated at Kumamoto University Hospital. Twenty-seven patients were optimally treated with various doses of imatinib. The mean (±SD) trough plasma concentrations of imatinib were 1.40 ± 0.57 μg/mL in 13 patients receiving 400 mg/day and 1.15 ± 0.44 μg/mL in 9 patients receiving 300 mg/day as an effective dose. Mean trough levels of the two groups were not significantly different and exceeded the effective plasma threshold. Body surface area (BSA) was significantly smaller in patients receiving the reduced dose compared with those receiving the standard dose (p = 0.001). The effective imatinib dose was associated with age and gender as well as BSA. A reduced dose of 300 mg/day of imatinib may be sufficient for the treatment of CML patients with smaller body size, particularly when intolerability arises. \nElectronic supplementary material  The online version of this article (doi:10.1007/s12185-009-0315-4) contains supplementary material, which is available to authorized users.","subitem_description_type":"Other"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12185-009-0315-4","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"0925-5710"}]}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.17","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"447480 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawaguchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"166449","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱田, 哲暢","creatorNameLang":"ja"},{"creatorName":"ハマダ, アキノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Akinobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"},{"familyName":"Hamada","familyNameLang":"en"}],"givenNames":[{"givenName":"哲暢","givenNameLang":"ja"},{"givenName":"アキノブ","givenNameLang":"ja-Kana"},{"givenName":"Akinobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Chie"}],"nameIdentifiers":[{"nameIdentifier":"166451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakashima, Reiko"}],"nameIdentifiers":[{"nameIdentifier":"166452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nambu, Takeru"}],"nameIdentifiers":[{"nameIdentifier":"166453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamakawa, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"166454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"166455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Horikawa, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"166456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsuya, Hiroaki"}],"nameIdentifiers":[{"nameIdentifier":"166457","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"齋藤, 秀之","creatorNameLang":"ja"},{"creatorName":"サイトウ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Saito, Hideyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"齋藤","familyNameLang":"ja"},{"familyName":"サイトウ","familyNameLang":"ja-Kana"},{"familyName":"Saito","familyNameLang":"en"}],"givenNames":[{"givenName":"秀之","givenNameLang":"ja"},{"givenName":"ヒデユキ","givenNameLang":"ja-Kana"},{"givenName":"Hideyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98307","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"IJH-KAWAGUCHI.pdf","filesize":[{"value":"447.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJH-KAWAGUCHI.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22638/files/IJH-KAWAGUCHI.pdf"},"version_id":"32f681a0-4336-4334-8e3a-1d3c1988e695"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chronic myeloid leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Imatinib","subitem_subject_scheme":"Other"},{"subitem_subject":"Trough level","subitem_subject_scheme":"Other"},{"subitem_subject":"Body surface area","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia","subitem_title_language":"en"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"22638","relation_version_is_last":true,"title":["Relationship between an effective dose of imatinib, body surface area, and trough drug levels in patients with chronic myeloid leukemia"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-09-14T07:09:02.934045+00:00"}