{"created":"2023-06-19T09:11:01.741823+00:00","id":22639,"links":{},"metadata":{"_buckets":{"deposit":"b2c1cc18-0aad-4d4d-9c6d-a3ba2732f4fb"},"_deposit":{"created_by":1,"id":"22639","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"22639"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00022639","sets":["415:416"]},"author_link":["98382","98384","98369","98372","98385","98383","98386","98387","98370","98368","98305","98388","98371","98374"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"2533","bibliographicPageStart":"2526","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Pharmaceutical Research"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森崎, 崇文"}],"nameIdentifiers":[{"nameIdentifier":"98382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松崎, 尊信"}],"nameIdentifiers":[{"nameIdentifier":"98383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横尾, 浩司"}],"nameIdentifiers":[{"nameIdentifier":"98384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"楠本, 将裕"}],"nameIdentifiers":[{"nameIdentifier":"98385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩田, 一史"}],"nameIdentifiers":[{"nameIdentifier":"98386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"濱田, 哲暢"}],"nameIdentifiers":[{"nameIdentifier":"98387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 秀之"}],"nameIdentifiers":[{"nameIdentifier":"98388","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Purpose  The purpose of this study was to examine the regulation of renal organic ion transporters in cisplatin-induced acute kidney injury (AKI) and its relation with indoxyl sulfate (IS), a uremic toxin. \nMethods  The IS concentrations in the serum and kidney were monitored by high-performance liquid chromatography. Uptake of p-aminohippuric acid, estrone-3-sulfate and tetraethylammonium were examined using renal slices. Real-time PCR and immunoblotting were performed to examine the mRNA and protein expression of rOATs, rOCTs and rMATE1 in the kidney, respectively. \nResults  The serum and renal IS levels were markedly elevated in cisplatin-treated rats. However, this effect was largely reversed by administration of AST-120, an oral charcoal adsorbent. The functions of renal basolateral organic anion and cation transporters were reduced in cisplatin-treated rats. The levels of mRNA and protein corresponding to rOAT1, rOAT3, rOCT2 and rMATE1, but not rOCT1, were depressed in the kidney of cisplatin-treated rats. Administration of AST-120 to cisplatin-treated rats partially restored the function and expression level of these transporters. \nConclusions  Cisplatin-induced AKI causes down-regulation of renal organic ion transporters accompanied by accumulation of serum and renal IS. IS could be involved in the mechanism of down-regulation of rOAT1, rOAT3 and rMATE1 under cisplatin-induced AKI.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.springerlink.com/content/t244462842j0v631/","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Netherlands"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11095-008-9668-2","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"07248741"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"},{"subitem_subject":"491.65","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"336690 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Morisaki, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"98368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuzaki, Takanobu"}],"nameIdentifiers":[{"nameIdentifier":"98369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoo, Koji"}],"nameIdentifiers":[{"nameIdentifier":"98370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusumoto, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"98371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwata, Kazufumi"}],"nameIdentifiers":[{"nameIdentifier":"98372","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"濱田, 哲暢","creatorNameLang":"ja"},{"creatorName":"ハマダ, アキノブ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Akinobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"濱田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"},{"familyName":"Hamada","familyNameLang":"en"}],"givenNames":[{"givenName":"哲暢","givenNameLang":"ja"},{"givenName":"アキノブ","givenNameLang":"ja-Kana"},{"givenName":"Akinobu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"98305","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"98374","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"PharmRes-MORISAKI_r.pdf","filesize":[{"value":"336.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PharmRes-MORISAKI_r.pdf","url":"https://kumadai.repo.nii.ac.jp/record/22639/files/PharmRes-MORISAKI_r.pdf"},"version_id":"c7ab19fa-c798-43b3-b847-c9a801fde708"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"acute kidney injury","subitem_subject_scheme":"Other"},{"subitem_subject":"cisplatin","subitem_subject_scheme":"Other"},{"subitem_subject":"indoxyl sulfate","subitem_subject_scheme":"Other"},{"subitem_subject":"organic anion transporter","subitem_subject_scheme":"Other"},{"subitem_subject":"organic cation transporter","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-26"},"publish_date":"2010-07-26","publish_status":"0","recid":"22639","relation_version_is_last":true,"title":["Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-14T07:09:01.522594+00:00"}