{"created":"2023-06-19T09:11:19.220927+00:00","id":23011,"links":{},"metadata":{"_buckets":{"deposit":"57cfee54-a38c-49ca-94f4-84b061b5b34e"},"_deposit":{"created_by":1,"id":"23011","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"23011"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00023011","sets":["407:432:477"]},"author_link":["100552","100553","100551","100571","100557","100555","100554","100559","94272","100556","100558"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"3893","bibliographicPageStart":"3887","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Antimicrobial Agents and Chemotherapy"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 誠治"}],"nameIdentifiers":[{"nameIdentifier":"100571","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"4'-Ethynyl-2-fluoro-2'-deoxyadenosine(EFdA), a recently discovered nucleoside reverse transcriptase inhibitor (NRTI), exhibits a wide spectrum of wild-type and multi-drug-resistant clinical HIV-1 isolates (EC50: 0.0001–0.001μM). In the present study, we used human peripheral blood mononuclear cell (hu-PBMC)-transplanted human immunodeficiency virus type 1 (HIV)-infected, NOD/SCID, janus kinase-3-knock-out (NOJ) mice for in vivo evaluation of the anti-HIV activity of EFdA. Administration of EFdA decreased the replication and cytopathic effects of HIV-1 without identifiable adverse effects. In PBS-treated mice, the CD4+/ CD8+ cell ratio in the spleen was low (median: 0.04, range 0.02–0.49), while that in mice receiving EFdA was increased (median: 0.65, range 0.57–1.43). EFdA treatment significantly suppressed the number of HIV-1 RNA (median: 9.0×102 copies/ml, range: 8.1×102-1.1×103; versus 9.9×104 copies/ml, range: 8.1×102–1.1×103; P < 0.001) and p24 level in plasma (2.5×103 range: 8.2×102–5.6×103 pg/ml, versus 2.8×102 range: 8.2×101–6.3×102 pg/ml; p<0.001) and p24+ cells in the spleen (1.90 %, range: 0.33–3.68, versus median: 0.11 %, range: 0.00–1.00, p=0.003) in comparison with PBS-treated mice. These data suggest that EFdA is a promising candidate for a new age of HIV-1 chemotherapy and should be further developed as a potential therapy for individuals with multidrug-resistant HIV-1 variants.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://aac.asm.org/cgi/content/abstract/53/9/3887?ck=nck","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology"}]},"item_16_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19546363","subitem_relation_type_select":"PMID"}}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/AAC.00270-09","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"00664804"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2009, American Society for Microbiology. All Rights Reserved."}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00542574","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"476825 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"100551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ide, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"100552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Hirotomo"}],"nameIdentifiers":[{"nameIdentifier":"100553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"100554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzu, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"100555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ashida, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"100556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kogo, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"100557","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Hayakawa, Hiroyuki","creatorNameLang":"en"},{"creatorName":"ハヤカワ, ヒロユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Hayakawa","familyNameLang":"en"},{"familyName":"ハヤカワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroyuki","givenNameLang":"en"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"100558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mitsuya, Hiroaki"}],"nameIdentifiers":[{"nameIdentifier":"100559","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"岡田, 誠治","creatorNameLang":"ja"},{"creatorName":"オカダ, セイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Seiji","creatorNameLang":"en"}],"familyNames":[{"familyName":"岡田","familyNameLang":"ja"},{"familyName":"オカダ","familyNameLang":"ja-Kana"},{"familyName":"Okada","familyNameLang":"en"}],"givenNames":[{"givenName":"誠治","givenNameLang":"ja"},{"givenName":"セイジ","givenNameLang":"ja-Kana"},{"givenName":"Seiji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94272","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Hattori 77.pdf","filesize":[{"value":"476.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hattori 77.pdf","url":"https://kumadai.repo.nii.ac.jp/record/23011/files/Hattori 77.pdf"},"version_id":"32efa324-cd1b-442f-bae9-f5eee08b5df5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse model","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleoside reverse transcriptase inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"NRTI","subitem_subject_scheme":"Other"},{"subitem_subject":"4’-ethynyl-2-fluoro-2’-deoxyadenosine","subitem_subject_scheme":"Other"},{"subitem_subject":"EFdA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Potent activity of a nucleoside reverse transcriptase inhibitor, 4′-ethynyl-2-fluoro-2′-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potent activity of a nucleoside reverse transcriptase inhibitor, 4′-ethynyl-2-fluoro-2′-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice"}]},"item_type_id":"16","owner":"1","path":["477"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-05"},"publish_date":"2009-11-05","publish_status":"0","recid":"23011","relation_version_is_last":true,"title":["Potent activity of a nucleoside reverse transcriptase inhibitor, 4′-ethynyl-2-fluoro-2′-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-30T00:37:57.090339+00:00"}