{"created":"2023-06-19T09:11:45.206865+00:00","id":23536,"links":{},"metadata":{"_buckets":{"deposit":"b9cf766e-9ce0-4018-8672-23529cb06c36"},"_deposit":{"created_by":127,"id":"23536","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"23536"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00023536","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03-24","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2000-03-24"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Recent studies have identified novel functions for class II MHC in addition to the presentation of antigenic peptides to CD4 +T cells. Signals transmitted by class II MHC molecules are important for regulating APC function. We examined effects of DR-mediated signaling on Ig production from B cells.\n最近の多くの研究により、クラスII MHC (major histocompatibility complex)分子はT細胞と抗原提示細胞が相互作用を起こす際に、抗原を提示する分子として機能するだけではなく、抗原提示細胞ヘ内向きのシグナルを入れることにより、抗原提示細胞自身を活性化するということが明らかとなってきた。本研究はクラスII分子を発現しているB細胞に注目し、B細胞上のHLA(human histocompatibility leucocyte antigen)-DR分子の架橋が免疫グロプリンの産生に与える影響を解析したものである。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1281号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学研究科"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1281号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田畑, 博己","creatorNameLang":"ja"},{"creatorName":"タバタ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tabata, Hiroki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1281.pdf","filesize":[{"value":"3.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1281.pdf","url":"https://kumadai.repo.nii.ac.jp/record/23536/files/22-1281.pdf"},"version_id":"e874e87c-3a4e-46c9-9b7f-fa0dc165eb7f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クラスII MHC分子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原提示細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"B細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA-DR分子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫グロブリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"HLA分子を介したシグナルによる免疫制御機構の解析 : B細胞上のHLA-DR分子の架橋により誘導されるSykの活性化を伴ったIgMの転写増強","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HLA分子を介したシグナルによる免疫制御機構の解析 : B細胞上のHLA-DR分子の架橋により誘導されるSykの活性化を伴ったIgMの転写増強","subitem_title_language":"ja"},{"subitem_title":"HLA ブンシ オ カイシタ シグナル ニ ヨル メンエキ セイギョ キコウ ノ カイセキ : Bサイボウジョウ ノ HLA-DR ブンシ ノ カキョウ ニ ヨリ ユウドウ サレル Syk ノ カッセイカ オ トモナッタ Igm ノ テンシャ ゾウキョウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Ligation of HLA-DR molecules on B cells induces up-regulated transcription of IgM heavy chain genes in association with Syk activation","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-03"},"publish_date":"2010-03-03","publish_status":"0","recid":"23536","relation_version_is_last":true,"title":["HLA分子を介したシグナルによる免疫制御機構の解析 : B細胞上のHLA-DR分子の架橋により誘導されるSykの活性化を伴ったIgMの転写増強"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:43:33.690613+00:00"}