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Metabolic dysfunction and circadian rhythm abnormalities in adolescents with sleep disturbanc
http://hdl.handle.net/2298/15330
http://hdl.handle.net/2298/15330bf82da2e-4b67-4cd5-a481-59ad599f6b78
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Tomoda_Neuroimage_rev_Feb-r.pdf (196.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-07-12 | |||||
| タイトル | ||||||
| タイトル | Metabolic dysfunction and circadian rhythm abnormalities in adolescents with sleep disturbanc | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Autonomic dysfunction, Cardiographic R-R interval, Circadian rhythm sleep disorders, Glucose metabolism; Human clock genes | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
友田, 明美
× 友田, 明美× Kawatani, Junko× Joudoi, Takako× 濱田, 哲暢× Miike, Teruhisa |
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| 別言語の著者 |
友田, 明美
× 友田, 明美× 川谷, 淳子× 上土井, 貴子× 濱田, 哲暢× 三池, 輝久 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background: Sleep disturbance attributable to circadian rhythm abnormalities frequently occurs in previously healthy children and adolescents who often complain of gastrointestinal discomfort after meals. Methods: Glucose metabolism, autonomic function, and human clock gene expression in whole blood cells were investigated in 18 adolescent patients with circadian rhythm sleep disorder. Results: Glucose tolerance was significantly lower in the patients than in normal controls: the mean sigma blood glucose level was significantly higher (P < 0.05) and the insulinogenic index was significantly lower (P < 0.05) in the patient group than in controls. Messenger ribonucleic acid level of hPer2 was significantly higher at 6:00 in the control subjects, but in only 3 of the 18 patients. Component analysis of cardiographic R-R interval revealed that high-frequency component peaks were suppressed significantly in the patient group compared to the controls (P < 0.001). Conclusions: Metabolic and endocrine dysfunctions were identified in adolescents with sleep disturbance as decreased glucose tolerance and absence of human clock gene regulation in whole blood cells. Their brain dysfunction attributable to sleep disturbances might cause such peripheral autonomic imbalance and carbohydrate metabolic dysfunction. | |||||
| 書誌情報 |
NeuroImage 巻 47, 号 SUPPL., p. T21-T26, 発行年 2009-08-02 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.neuroimage.2009.02.038 | |||||
| 権利 | ||||||
| 権利情報 | © 2009 Elsevier Inc. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 10538119 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 196477 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.9 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNP-4VSB18R-5&_user=4545557&_coverDate=08%2F31%2F2009&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=a19b5494359a0d175a51e6b751abcdee | |||||
