@article{oai:kumadai.repo.nii.ac.jp:00023988,
 author = {指宿, 睦子 and 山本, 豊 and Yamamoto, Yutaka and 川添, 輝 and 白石, 慎哉 and 冨口, 静二 and 山下, 康行 and Yamashita, Yasuyuki and 本田, 由美 and Honda, Yumi and 猪山, 賢一 and 岩瀬, 弘敬 and Ibusuki, Mutsuko and 山本, 豊 and Yamamoto, Yutaka and Kawasoe, Teru and Shiraishi, Shinya and 冨口, 静二 and Tomiguchi, Seiji and 山下, 康行 and Yamashita, Yasuyuki and 本田, 由美 and Honda, Yumi and Iyama, Kenichi and Iwase, Hirotaka},
 issue = {2},
 journal = {Surgical Oncology},
 month = {Jun},
 note = {application/pdf, 論文(Article), Objective: This study aims to assess the role of three dimensional single-photon emission computed tomography (3D-SPECT/CT) in sentinel node (SN) identification, and to analyze the impact of such information on estimating metastases to SNs. nBackground: Nodal status is a key factor for breast cancer. SN biopsy has been established as the alternative to routine axillary dissection these days. We investigated both the anatomical location of SNs demonstrated by our 3D-SPECT/CT system and the correlation to SNpositivity. nMethods: Two hundred and twenty-three clinically node-negative patients underwent SN biopsy. All of the axillary structures, including SNs, were visualized by a SPECT/CTcombined system after subcutaneous injection of 99mTc-phytate. By plotting the visualized SNs, the most frequent SN location ‘Pedestal area (PA)’ was designated. nResults: SPECT/CT detected 99mTc uptake in 217 cases (97.3%). 3D-SPECT/CT images visualized the accurate location of SNs in each case. In patients whose SNs were histopathologically negative (SN-), 228 (98.3%) SNs were found in the PA, and 4 (1.7%) were in other zones. In those with histopathologically positive SNs (SN+), 65 (78.3%) SNs were in the PA and 18 (21.7%) were outside it. The difference in SN distribution (i.e., in or out of the PA) between SN+ and SN- patients was statistically significant (p<0.001, chi-square test). nConclusions: SN biopsy navigated by 3D-SPECT/CT can clarify the reoperative anatomical localization of SNs in patients with breast cancer. Atypical distribution of SNs out of the PA may suggest SN positivity, reflecting failure of the lymphatic drainage systems.},
 pages = {88--94},
 title = {Potential advantage of preoperative three-dimensional mapping of sentinel nodes in breast cancer by a hybrid single photon emission CT (SPECT)/CT system},
 volume = {19},
 year = {2010},
 yomi = {ヤマモト, ユタカ and ヤマシタ, ヤスユキ and ホンダ, ユミ and ヤマモト, ユタカ and トミグチ, セイジ and ヤマシタ, ヤスユキ and ホンダ, ユミ}
}