{"created":"2023-06-19T09:12:17.883578+00:00","id":24119,"links":{},"metadata":{"_buckets":{"deposit":"90f4d777-2380-418a-8ec0-a2c827aca748"},"_deposit":{"created_by":127,"id":"24119","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"24119"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024119","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2009-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"皮膚・骨格筋など生検可能組織で観察されるGOM は、CADASIL の診断および研究の対象として注目されている(Rhuchoux MM, et al., 1995; Tikka S, et al.,2009)。しかし、GOM の検出には、これまで電子顕微鏡が不可欠とされ、一般に行われている組織化学染色による光学顕微鏡では検出困難とされてきた。今後、CADASIL の病理学的診断を普遍化し、病態解明研究を促進するためには、光学顕微鏡レベルでGOM を検出できるか否かが重要なポイントとなる。そこで、本研究ではGOM が光学顕微鏡で検出可能であるか、またその所見がどのようなものであるかを詳細に検討することを目的とした。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1702号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1702号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"植田, 明彦","creatorNameLang":"ja"},{"creatorName":"ウエダ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Akihiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1702.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1702.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24119/files/22-1702.pdf"},"version_id":"c49a3c98-3653-4d50-8b52-2c1d0dbb5ec7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CADASIL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GOM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"光学顕微鏡","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症の Granular Osmiophilic Material の光学顕微鏡による検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症の Granular Osmiophilic Material の光学顕微鏡による検出","subitem_title_language":"ja"},{"subitem_title":"ヒシツカ コウソク ト ハクシツ ノウショウ オ トモナウ ジョウ センショクタイ ユウセイ ノウ ドウミャクショウ ノ Granular Osmiophilic Material ノ コウガク ケンビキョウ ニ ヨル ケンシュツ","subitem_title_language":"ja-Kana"},{"subitem_title":"Detection of Granular Osmiophilic Material of CADASIL by Light Microscopy","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-10-26"},"publish_date":"2010-10-26","publish_status":"0","recid":"24119","relation_version_is_last":true,"title":["皮質下梗塞と白質脳症を伴う常染色体優性脳動脈症の Granular Osmiophilic Material の光学顕微鏡による検出"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:45:44.509598+00:00"}