{"created":"2023-06-19T09:12:18.784688+00:00","id":24135,"links":{},"metadata":{"_buckets":{"deposit":"86e8ae82-3e44-4660-898b-5075ee7dcb1a"},"_deposit":{"created_by":127,"id":"24135","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"24135"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024135","sets":["343:347:348:497"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2009-12-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（生命科学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年，AAA (ATPases Associated with various cellular Activities) タンパク質に起因するヒト疾患が相次いで報告されている。AAA タンパク質の一つであるspastin は，重篤な神経変性疾患である遺伝性痙性対麻痺の原因因子として同定された。最近，培養細胞およびショウジョウバエを用いた実験により，spastin が微小管切断活性を示すことが報告されている。しかしながら，spastin が微小管とどのように相互作用し，その後どのようなメカニズムで微小管を切断するかは明らかになっていない。そこで本研究では，これらを明らかにするため，線虫のspastin ホモログであるSPAS-1 の生化学的・構造生物学的解析を行った。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第7号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　生体医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博生命第7号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石踊, 由佳","creatorNameLang":"ja"},{"creatorName":"イシオドリ, ユカ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishiodori, Yuka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"51-0007.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"51-0007.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24135/files/51-0007.pdf"},"version_id":"d9b93c35-5ed0-4643-b064-575b9cc2790f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AAA タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性痙性対麻痺","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Spastin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"線虫ホモログ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"SPAS-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能","subitem_title_language":"ja"},{"subitem_title":"ビショウカン セツダン カッセイ オ モツ AAA タンパクシツ spastin ノ センチュウ ホモログ ノ コウゾウ ト キノウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Structure and function of the Caenorhabditis elegans homologue of spastin, a member of AAA protein with microtubule-severing activity","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["497"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-10-28"},"publish_date":"2010-10-28","publish_status":"0","recid":"24135","relation_version_is_last":true,"title":["微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-28T05:02:56.619147+00:00"}