{"created":"2023-06-19T09:12:18.784688+00:00","id":24135,"links":{},"metadata":{"_buckets":{"deposit":"86e8ae82-3e44-4660-898b-5075ee7dcb1a"},"_deposit":{"created_by":1,"id":"24135","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24135"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024135","sets":["343:347:348:497"]},"author_link":["106709","106711","106710"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Structure and function of the Caenorhabditis elegans homologue of spastin, a member of AAA protein with microtubule-severing activity"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ビショウカン セツダン カッセイ オ モツ AAA タンパクシツ spastin ノ センチュウ ホモログ ノ コウゾウ ト キノウ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishiodori, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"106711","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"近年，AAA (ATPases Associated with various cellular Activities) タンパク質に起因するヒト疾患が相次いで報告されている。AAA タンパク質の一つであるspastin は，重篤な神経変性疾患である遺伝性痙性対麻痺の原因因子として同定された。最近，培養細胞およびショウジョウバエを用いた実験により，spastin が微小管切断活性を示すことが報告されている。しかしながら，spastin が微小管とどのように相互作用し，その後どのようなメカニズムで微小管を切断するかは明らかになっていない。そこで本研究では，これらを明らかにするため，線虫のspastin ホモログであるSPAS-1 の生化学的・構造生物学的解析を行った。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"3800411 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or 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タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性痙性対麻痺","subitem_subject_scheme":"Other"},{"subitem_subject":"Spastin","subitem_subject_scheme":"Other"},{"subitem_subject":"線虫ホモログ","subitem_subject_scheme":"Other"},{"subitem_subject":"SPAS-1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能"}]},"item_type_id":"14","owner":"1","path":["497"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-28"},"publish_date":"2010-10-28","publish_status":"0","recid":"24135","relation_version_is_last":true,"title":["微小管切断活性をもつAAAタンパク質spastinの線虫ホモログの構造と機能"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:28:20.294701+00:00"}