{"created":"2023-06-19T09:12:19.230351+00:00","id":24144,"links":{},"metadata":{"_buckets":{"deposit":"fef180dd-33cd-40ba-999e-f2332f4df704"},"_deposit":{"created_by":127,"id":"24144","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"24144"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024144","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"悪性グリオーマは近年の診断・治療技術の進歩にも関わらず、多様な病態と治療抵抗性のため、未だ十分な治療成績が得られていない難治性の脳腫瘍である。抗がん剤や放射線によってDNA や染色体に損傷を与えると、染色体不安定性が誘導され、染色体の大きな構造異常が細胞分裂を繰り返すたびに生み出される。悪性グリオーマにおいては顕著な染色体不安定性が見られ、この特性が悪性グリオーマの病態と関連していると考えられる。従って、悪性グリオーマの染色体不安定性の要因を探索し、その病態を解明することは新たな治療法の開発に重要である。本研究において、DNA の組換えを制御する核内分子germinal center-associated nuclear protein (GANP)がその要因となることを明らかにした。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1727号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1727号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大田, 和貴","creatorNameLang":"ja"},{"creatorName":"オオタ, カズタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohta, Kazutaka","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1727.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1727.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24144/files/22-1727.pdf"},"version_id":"94284c7b-1040-4f78-8f48-42b5c8f09d36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"悪性グリオーマ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"GANP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SAC3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"悪性グリオーマにおいてGANPの発現低下は染色体不安定性に関与し、予後不良因子となる","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"悪性グリオーマにおいてGANPの発現低下は染色体不安定性に関与し、予後不良因子となる","subitem_title_language":"ja"},{"subitem_title":"アクセイ グリオーマ ニ オイテ GANP ノ ハツゲン テイカ ワ センショクタイ フアンテイセイ ニ カンヨ シ ヨゴ フリョウ インシ ト ナル","subitem_title_language":"ja-Kana"},{"subitem_title":"Decreased expression of GANP associated with chromosomal instability is a poor prognostic factor in malignant gliomas","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-02"},"publish_date":"2010-11-02","publish_status":"0","recid":"24144","relation_version_is_last":true,"title":["悪性グリオーマにおいてGANPの発現低下は染色体不安定性に関与し、予後不良因子となる"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:46:23.045601+00:00"}