{"created":"2023-06-19T09:12:20.625367+00:00","id":24165,"links":{},"metadata":{"_buckets":{"deposit":"4669cb7a-8662-4039-a1a1-68bdb4eef0bd"},"_deposit":{"created_by":1,"id":"24165","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24165"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024165","sets":["413:414","585:610:1244"]},"author_link":["158936","158233"],"item_15_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study on Abnormality of Reactive Oxygen Species Production by Lymphocytes of Patients with Systemic Lupus Erythematosus"}]},"item_15_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ゼンシン セイ エリテマトーデス ニ オケル リンパ キュウ カッセイ サンソ ノ イジョウ ニ ツイテ"}]},"item_15_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"42","bibliographicPageStart":"33","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"熊本大学医療技術短期大学部紀要"}]}]},"item_15_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石井, 俊徳","creatorNameLang":"ja"},{"creatorName":"イシイ, トシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishii, Toshinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"石井","familyNameLang":"ja"},{"familyName":"イシイ","familyNameLang":"ja-Kana"},{"familyName":"Ishii","familyNameLang":"en"}],"givenNames":[{"givenName":"俊徳","givenNameLang":"ja"},{"givenName":"トシノリ","givenNameLang":"ja-Kana"},{"givenName":"Toshinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"158233","nameIdentifierScheme":"WEKO"}]}]},"item_15_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_15_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_15_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"自己免疫性疾患の一つであるSLE患者のリンパ球について活性酸素産生異常の有無を調べ、リンパ球機能、サイトカイン、細胞接着分子との関係について考察した。","subitem_description_type":"Other"},{"subitem_description":"To elucidate the role of reactive oxygen species (ROS) on pathogenesis of systemic lupus erythematosus (SLE), I measured ROS produced in lymphocytes of patients with SLE by flow cytometry method. In SLE lymphocytes, significant increase of ROS were observed in B cells and natural killer (NK) cells in comparison with ones in lymphocytes of healthy persons. In the other subsets of lymphocytes, level of ROS were also upward tendency in SLE. Inflammatory cytokines such as interleukin-1 beta, tumor necrosis factor-alpha and interferon gamma did not concern with high level of ROS in SLE. There was nothing wrong with suppressor function of monocytes on ROS production. Significant positive correlation was observed between ROS production and expression of cell adhesion molecule CD29 in SLE. Therefore lymphocytes which infiltrate into organs by adhesion to endothelial cells must have high level of ROS. I speculate that high level of ROS produced in lymphocytes is related with autoantibody production in B cells and malfunction on elimination of autoreactive cells in NK cells, and that these abnormalities lead to onset and aggravation of SLE.","subitem_description_type":"Other"}]},"item_15_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_15_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09181512","subitem_source_identifier_type":"ISSN"}]},"item_15_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10401515","subitem_source_identifier_type":"NCID"}]},"item_15_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.14","subitem_subject_scheme":"NDC"}]},"item_15_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"3223077 bytes"}]},"item_15_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_15_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_15_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_15_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"02"}]},"item_15_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石井, 俊徳"}],"nameIdentifiers":[{"nameIdentifier":"158936","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"MT0009_033-042.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MT0009_033-042.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24165/files/MT0009_033-042.pdf"},"version_id":"00723a9a-1a1b-4832-8ee5-53e1d50a8426"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Reactive Oxygen Species (ROS)","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic Lupus Erythematosus (SLE)","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Adhesion Molecule","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全身性エリテマトーデスにおけるリンパ球活性酸素の異常について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性エリテマトーデスにおけるリンパ球活性酸素の異常について"}]},"item_type_id":"15","owner":"1","path":["414","1244"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-08"},"publish_date":"2010-11-08","publish_status":"0","recid":"24165","relation_version_is_last":true,"title":["全身性エリテマトーデスにおけるリンパ球活性酸素の異常について"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-05T06:29:21.865038+00:00"}