@article{oai:kumadai.repo.nii.ac.jp:00024167,
 author = {石井, 俊徳 and Ishii, Toshinori and 石井, 俊徳},
 journal = {熊本大学医療技術短期大学部紀要},
 month = {Mar},
 note = {application/pdf, 論文(Article), リンパ球に活性酸素産生能があるか、実際に活性酸素を産生していつかについてリンパ球のサブセット別に測定し、機能との関連を考察したので、ここに報告する。, Productivity and native production of reactive oxygen species (ROS) by peripheral blood lymphocyte subsets in healthy persons were examined with flow cytometry method. All of lymphocyte subsets showed productivity of ROS as they responded to stimulation with phorbor myristate acetate (PMA). When ROS were measured in non-stimulation state to detect native, ROS production CD4+ and CD19+ lymphocytes produced relative high levels of ROS, but CD8+ ones produced relative low level of ROS, and CD56+ ones produced lowest level or little of ROS. Antibodies to CD4 and CD19 induced ROS production in lymphocyte subsets of CD4 and CD19 respectively. But neither antibody to CD8 nor to CD56 stimulated each lymphocyte subset. Both interleukin-1beta and tumor necrosis factor-alpha enhanced ROS production in lymphocytes, but interferon-gamma hadn't stimulation ability. Stimulation with antibodies through cell adhesion molecules of CD15s, CD49d and CD62L also enhanced ROS production in lymphocytes. These studies demonstrate that state of ROS production is different in each lymphocyte subset and that the difference is due to devergence of response in each subset to stimulation through cell surface antigens such as cell adhesion molecules and cytokine receptors. The roles of ROS produced in lymphocyte are thought to be related to cell proliferation and control of gene expression. Therefore study of ROS in lymphocyte subsets could be expected to elucidate pathogenesis of autoimmune diseases and lymphoid malignancies.},
 pages = {63--73},
 title = {リンパ球の活性酸素産生},
 volume = {8},
 year = {1998},
 yomi = {イシイ, トシノリ}
}