{"created":"2023-06-19T09:12:21.152614+00:00","id":24175,"links":{},"metadata":{"_buckets":{"deposit":"43566e85-36de-4203-9e1b-bcac076709f4"},"_deposit":{"created_by":1,"id":"24175","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24175"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024175","sets":["343:347:348:349"]},"author_link":["106931","106932","106930"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Identification of a novel tumor-associated antigen, SPARC, as a possible target for immunotherapy of gastric, colorectal, and pancreatic cancers"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シンキ ガン コウゲン SPARC オ ヒョウテキ トシタ ガン メンエキ リョウホウ ノ カイハツ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Mitsuhiro"}],"nameIdentifiers":[{"nameIdentifier":"106932","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"cDNAマイクロアレイ解析により、スキルス胃癌に高発現する新規癌関連抗原遺伝子として、SPARC (Secreted Protein Acidic and Rich in Cysteine) が同定されている。また、すでにSPARCは、マウスにおいて抗腫瘍免疫を誘導できることが知られている。本研究は、SPARCによるヒト細胞傷害性T細胞(CTL) の誘導を検討し、SPARCを標的とした癌免疫療法の可能性を探ることを目的とする。","subitem_description_type":"Other"},{"subitem_description":"It is important to identify tumor-associated antigens (TAAs) to direct the immune system to attack cancer in order to establish efficient anti-cancer-immunotherapy. A genome-wide cDNA microarray analysis identified that SPARC gene is overexpressed in the gastric, pancreatic and colorectal cancer tissues but not in their non-cancerous counterparts. This study attempted to identify HLA-A24 (A*2402)-restricted and SPARC derived CTL epitopes.","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1990230 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"熊本大学大学院医学教育部　臨床医科学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1744号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 光弘"}],"nameIdentifiers":[{"nameIdentifier":"106930","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1744.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1744.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24175/files/22-1744.pdf"},"version_id":"3e5cacb4-0086-4945-8bb6-5c4d595dbbec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CTL","subitem_subject_scheme":"Other"},{"subitem_subject":"CDNAマイクロアレイ","subitem_subject_scheme":"Other"},{"subitem_subject":"SPARC遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"NOD/Shi-scid IL2rgammanull(NOG)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"新規癌抗原SPARCを標的とした癌免疫療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規癌抗原SPARCを標的とした癌免疫療法の開発"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-09"},"publish_date":"2010-11-09","publish_status":"0","recid":"24175","relation_version_is_last":true,"title":["新規癌抗原SPARCを標的とした癌免疫療法の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:27:35.069755+00:00"}