{"created":"2023-06-19T09:12:21.356271+00:00","id":24178,"links":{},"metadata":{"_buckets":{"deposit":"c232be84-494c-4411-a3a8-b3ef8ba021a2"},"_deposit":{"created_by":1,"id":"24178","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24178"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024178","sets":["413:414","585:612:1267"]},"author_link":["158233"],"item_15_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relationship between lymphocytopenia and reactive oxygen species of lymphocytes in systemic lupus erythematosus"}]},"item_15_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ゼンシン セイ エリテマトーデス ニ オケル リンパ キュウ ゲンショウ ト リンパ キュウ カッセイ サンソ ノ カンケイ"}]},"item_15_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"53","bibliographicPageStart":"47","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"熊本大学医学部保健学科紀要"}]}]},"item_15_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石井, 俊徳","creatorNameLang":"ja"},{"creatorName":"イシイ, トシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishii, Toshinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"石井","familyNameLang":"ja"},{"familyName":"イシイ","familyNameLang":"ja-Kana"},{"familyName":"Ishii","familyNameLang":"en"}],"givenNames":[{"givenName":"俊徳","givenNameLang":"ja"},{"givenName":"トシノリ","givenNameLang":"ja-Kana"},{"givenName":"Toshinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"158233","nameIdentifierScheme":"WEKO"}]}]},"item_15_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_15_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_15_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"SLEにおいてリンパ球減少は診断および活動性評価の重要な所見である。リンパ球ROSとリンパ球減少との関係を調べてみた結果、有意の負の相関がみられた。またROSはFas陽性率やアポトーシス発現率と正の相関がみられた。この結果はROSがリンパ球減少を引き起こすアポトーシス経路に密接に関わっていることを示唆している。","subitem_description_type":"Other"},{"subitem_description":"Lymphocytopenia is an important laboratory finding in diagnosis and disease activity estimation of systemic lupus erythematosus. Here, I demonstrated that the amount of reactive oxygen species (ROS) produced by lymphocytes was negatively correlated with the number of lymphocytes in peripheral blood, and that the former was also positively correlated with both Fas positive rates and apoptosis rates of lymphocytes. These results suggest that ROS is necessary for the process of apoptosis which triggers lymphocytopenia in systemic lupus erythematosus.","subitem_description_type":"Other"}]},"item_15_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_15_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18807151","subitem_source_identifier_type":"ISSN"}]},"item_15_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12010572","subitem_source_identifier_type":"NCID"}]},"item_15_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.14","subitem_subject_scheme":"NDC"}]},"item_15_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"1952250 bytes"}]},"item_15_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_15_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_15_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_15_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"02"}]},"item_15_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"石井, 俊徳","creatorNameLang":"ja"},{"creatorName":"イシイ, トシノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishii, Toshinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"石井","familyNameLang":"ja"},{"familyName":"イシイ","familyNameLang":"ja-Kana"},{"familyName":"Ishii","familyNameLang":"en"}],"givenNames":[{"givenName":"俊徳","givenNameLang":"ja"},{"givenName":"トシノリ","givenNameLang":"ja-Kana"},{"givenName":"Toshinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"158233","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"MH0002_047-053.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MH0002_047-053.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24178/files/MH0002_047-053.pdf"},"version_id":"5919308e-6bc2-400e-b063-ca6d45adeca8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SLE","subitem_subject_scheme":"Other"},{"subitem_subject":"ROS","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphocytopenia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全身性エリテマトーデスにおけるリンパ球減少とリンパ球活性酸素の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性エリテマトーデスにおけるリンパ球減少とリンパ球活性酸素の関係"}]},"item_type_id":"15","owner":"1","path":["414","1267"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-10"},"publish_date":"2010-11-10","publish_status":"0","recid":"24178","relation_version_is_last":true,"title":["全身性エリテマトーデスにおけるリンパ球減少とリンパ球活性酸素の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-05T06:29:21.279878+00:00"}