{"created":"2023-06-19T09:12:21.769965+00:00","id":24184,"links":{},"metadata":{"_buckets":{"deposit":"751e9496-70df-4dff-aa97-d83688f52ffa"},"_deposit":{"created_by":127,"id":"24184","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"24184"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024184","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2010-03-25"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"アルドステロンの非上皮組織における多面的な作用が注目されているが、直接的な心血管障害の分子機序は不明である。今回、Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK)のひとつであるApoptosis-Signal Regulating Kinase 1 (ASK1)の、アルドステロン誘導性心血管障害における役割を検討した。 野生型マウスとASK1 ノックアウトマウス(ASK1-/-)に1%食塩水を飲水投与し、それぞれコントロール群、アルドステロン投与群、アルドステロン投与＋塩化カリウム補充群の３群に分けた。浸透圧ポンプを用いてアルドステロンを４週間持続注入後、心血管および腎障害、炎症、酸化ストレス、およびレニン-アンジオテンシン(RA)系への影響を比較検討した。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The molecular mechanism underlying aldosterone-mediated\ncardiac injury is unclear. We examined the role of ASK1, a MAPKKK, in\naldosterone (ALD)/salt-induced cardiac injury in vivo. ALD was infused into\nwild-type and ASK1 deficient (ASK1-/-) mice for 4 weeks. Both strains of mice\nmaintained on 1% NaCl drinking water were divided into 3 groups, including\nsaline infusion (control), ALD infusion, or ALD infusion plus 0.3% KCl\nsupplementation, to compare the in vivo effects of ALD/salt treatment.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1732号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"熊本大学大学院医学教育部　病態制御学専攻"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1732号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 太志","creatorNameLang":"ja"},{"creatorName":"ナカムラ, タイシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Taishi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1732.pdf","filesize":[{"value":"737.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1732.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24184/files/22-1732.pdf"},"version_id":"8e093705-c08d-48e9-800e-394a0926e0d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アルドステロン","subitem_subject_language":"ja-Kana","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis signal-regulating kinase 1 (ASK1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"心血管疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"NADPH オキシダーゼ","subitem_subject_language":"ja-Kana","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"食塩/アルドステロンによる心臓の炎症と線維化促進の分子機序 : ASK1を介する酸化ストレス亢進と組織レニン・アンジオテンシン系活性化の重要性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食塩/アルドステロンによる心臓の炎症と線維化促進の分子機序 : ASK1を介する酸化ストレス亢進と組織レニン・アンジオテンシン系活性化の重要性","subitem_title_language":"ja"},{"subitem_title":"ショクエン アルドステロン ニ ヨル シンゾウ ノ エンショウ ト センイカ ソクシン ノ ブンシ キジョ : ASK1 オ カイスル サンカ ストレス コウシン ト ソシキ レニン アンジオテンシン ケイ カッセイカ ノ ジュウヨウセイ","subitem_title_language":"ja-Kana"},{"subitem_title":"The molecular mechanism of aldosterone/salt-induced cardiac inflammation and fibrosis : critical role of the enhancement of cardiac oxidative stress and the activation of cardiac renin-angiotensin system, via apoptois signal-regulating kinase 1 (ASK1)","subitem_title_language":"en"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-10"},"publish_date":"2010-11-10","publish_status":"0","recid":"24184","relation_version_is_last":true,"title":["食塩/アルドステロンによる心臓の炎症と線維化促進の分子機序 : ASK1を介する酸化ストレス亢進と組織レニン・アンジオテンシン系活性化の重要性"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:47:25.947386+00:00"}