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Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses
http://hdl.handle.net/2298/17476
http://hdl.handle.net/2298/17476bb397dd8-9a5b-4cca-b396-124a40520f64
| 名前 / ファイル | ライセンス | アクション |
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JOV2010_84_11_Supplemental Figure.pdf (23.7 kB)
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JOV2010_84_11_5508-5519.pdf (660.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-01-04 | |||||
| タイトル | ||||||
| タイトル | Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Koizumi, Hirokazu
× Koizumi, Hirokazu× Hashimoto, Masao× Fujiwara, Mamoru× Murakoshi, Hayato× Chikata, Takayuki× Ali Borghan, Mohamed× Hachiya, Atsuko× Kawashima, Yuka× 高田, 比呂志× Ueno, Takamasa× Oka, Shinichi× Takiguchi, Masafumi |
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| 別言語の著者 |
小泉, 寛和
× 小泉, 寛和× 端本, 昌夫× 藤原, 守× 村越, 勇人× 蜂谷, 敦子× 川島, 夕佳× 高田, 比呂志× 上野, 貴将× 岡, 慎一× 滝口, 雅文 |
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| 内容記述 | ||||||
| 内容記述 | HIV-1 escape mutants are well known to be selected by immune pressure via HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies. The ability of the CTLs to suppress HIV-1 replication is assumed to be associated with the selection of escape mutants from the CTLs. Therefore, we first investigated the correlation between the ability of HLA-A*1101-restricted CTLs recognizing immunodominant epitopes in vitro and the selection of escape mutants. The result showed that there was no correlation between the ability of these CTLs to suppress HIV-1 replication in vitro and the appearance of escape mutants. The CTLs that had a strong ability to suppress HIV-1 replication in vitro but failed to select escape mutants expressed a higher level of PD-1 in vivo, whereas those that had a strong ability to suppress HIV-1 replication in vitro and selected escape mutants expressed a low level of PD-1. Ex vivo analysis of these CTLs revealed that the latter CTLs had a significantly stronger ability to recognize the epitope than the former ones. These results suggest that escape mutations are selected by HIV-1-specific CTLs that have a stronger ability to recognize HIV-1 in vivo but not in vitro. | |||||
| 書誌情報 |
Journal of Virology 巻 84, 号 11, p. 5508-5519, 発行年 2010-06 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20335254 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1128/JVI.02483-09 | |||||
| 権利 | ||||||
| 権利情報 | © 2010, American Society for Microbiology. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 0022538X | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 660907 bytes | ||||||
| 形態 | ||||||
| 23673 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.878 | |||||
| 出版者 | ||||||
| 出版者 | American Society for Microbiology | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| text | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://jvi.asm.org/cgi/content/abstract/84/11/5508 | |||||
