@article{oai:kumadai.repo.nii.ac.jp:00024202,
 author = {Tsukamoto, Sachiko and Yamanokuchi, Rumi and Yoshitomi, Makiko and Sato, Kohei and Ikeda, Tsuyoshi and Rotinsulu, Henki and E. P. Mangindaan, Remy and J. de Voogd, Nicole and W. M. van Soest, Rob and Yokosawa, Hideyoshi},
 issue = {11},
 journal = {Bioorganic and Medicinal Chemistry Letters},
 month = {Jun},
 note = {Aaptamine (1), isoaaptamine (2), and demethylaaptamine (3) were isolated from the marine sponge Aaptos suberitoides collected in Indonesia as inhibitors of the proteasome. They inhibited the chymotrypsin-like and caspase-like activities of the proteasome with IC50 values of 1.6-4.6 μg/mL, while they showed less inhibition of the trypsin-like activity of the proteasome. The three compounds showed cytotoxic activities against HeLa cells, but their cytotoxicity did not correlate with their potency as proteasome inhibitors, strongly suggesting that their proteasomal inhibitory activity is dispensable to their cytotoxicity.},
 pages = {3341--3343},
 title = {Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor},
 volume = {20},
 year = {2010}
}