{"created":"2023-06-19T09:12:22.839447+00:00","id":24202,"links":{},"metadata":{"_buckets":{"deposit":"2d3b6013-1092-4526-9522-af837f05941b"},"_deposit":{"created_by":12,"id":"24202","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"24202"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024202","sets":["415:416"]},"author_link":["147106","107200","107185","107186","107187","107188","107189","107190","107191","107192"],"control_number":"24202","item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"3343","bibliographicPageStart":"3341","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Bioorganic and Medicinal Chemistry Letters","bibliographic_titleLang":"en"}]}]},"item_16_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aaptamine (1), isoaaptamine (2), and demethylaaptamine (3) were isolated from the marine sponge Aaptos suberitoides collected in Indonesia as inhibitors of the proteasome. They inhibited the chymotrypsin-like and caspase-like activities of the proteasome with IC50 values of 1.6-4.6 μg/mL, while they showed less inhibition of the trypsin-like activity of the proteasome. The three compounds showed cytotoxic activities against HeLa cells, but their cytotoxicity did not correlate with their potency as proteasome inhibitors, strongly suggesting that their proteasomal inhibitory activity is dispensable to their cytotoxicity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV","subitem_publisher_language":"en"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmcl.2010.04.029","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) Copyright 2010 Elsevier B.V.","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"PISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukamoto, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanokuchi, Rumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshitomi, Makiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeda, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rotinsulu, Henki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"E. 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M. van Soest, Rob","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokosawa, Hideyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107192","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"BMCL20_11_3341-3343.pdf","filesize":[{"value":"203.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCL20_11_3341-3343.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24202/files/BMCL20_11_3341-3343.pdf"},"version_id":"ada69081-2673-4d4c-b525-31f9dc441148"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"proteasome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chymotrypsin-like activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sponge","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alkaloid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor","subitem_title_language":"en"}]},"item_type_id":"16","owner":"12","path":["416"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-18"},"publish_date":"2010-11-18","publish_status":"0","recid":"24202","relation_version_is_last":true,"title":["Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-05T04:14:44.883469+00:00"}