{"created":"2023-06-19T09:12:23.378374+00:00","id":24210,"links":{},"metadata":{"_buckets":{"deposit":"db96ee7c-c5ff-420e-90f2-b784a5e3b6be"},"_deposit":{"created_by":1,"id":"24210","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24210"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024210","sets":["415:416"]},"author_link":["107243","107240","107244","107242","107247","107241","107239","107248"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"134","bibliographicPageStart":"127","bibliographicVolumeNumber":"393","bibliographic_titles":[{"bibliographic_title":"International Journal of Pharmaceutics"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本山, 敬一"}],"nameIdentifiers":[{"nameIdentifier":"107247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"有馬, 英俊"}],"nameIdentifiers":[{"nameIdentifier":"107248","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Topical application of nuclear factor-κB (NF-κB) decoy appears to provide a novel therapeutic potency in the treatment of inflammation and atopic dermatitis.  However, it is difficult to deliver NF-κB decoy oligonucleotides (ODN) into the skin by conventional methods based on passive diffusion because of its hydrophilicity and high molecular weight.  In this study, we evaluated the in vitro transdermal delivery of fluorescein isothiocyanate (FITC)-NF-κB decoy ODN using a pulse depolarization (PDP) iontophoresis.  In vitro iontophoretic experiments were performed on isolated C57BL/6 mice skin using a horizontal diffusion cell.  The apparent flux values of FITC-NF-κB decoy ODN were enhanced with increasing the current density and NF-κB decoy ODN concentration by iontophoresis.  Accumulation of FITC-NF-κB decoy ODN was observed at the epidermis and upper dermis by iontophoresis.  In mouse model of skin inflammation, iontophoretic delivery of NF-κB decoy ODN significantly reduced the increase in ear thickness caused by phorbol ester as well as the protein and mRNA expression levels of tumor necrosis factor-α (TNF-α) in the mice ears.  These results suggest that iontophoresis is a useful and promising enhancement technique for transdermal delivery of NF-κB decoy ODN.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"https://www.sciencedirect.com/science/article/pii/S0378517310002929?via%3Dihub","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijpharm.2010.04.020","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"03785173"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 Elsevier B.V."}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"192322 bytes"},{"subitem_text_value":"165695 bytes"},{"subitem_text_value":"57478 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Abu Hashim, Irhan Ibrahim, ","creatorNameLang":"en"}],"familyNames":[{"familyName":"Abu Hashim, Irhan Ibrahim","familyNameLang":"en"}],"givenNames":[{"givenName":"","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"107239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motoyama, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"107240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Helmy Abd-ElGawad, Abd-ElGawad"}],"nameIdentifiers":[{"nameIdentifier":"107241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"H. El-Shabouri, Mohamed"}],"nameIdentifiers":[{"nameIdentifier":"107242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Thanaa Mohamed Borg"}],"nameIdentifiers":[{"nameIdentifier":"107243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arima, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"107244","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Iontophoresis-Table-submit-R1.pdf","filesize":[{"value":"57.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Iontophoresis-Table-submit-R1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24210/files/Iontophoresis-Table-submit-R1.pdf"},"version_id":"b8627bda-d0e4-465d-9ab0-7e528daceb46"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Iontophoresis-Fig-submit-R1.pdf","filesize":[{"value":"165.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Iontophoresis-Fig-submit-R1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24210/files/Iontophoresis-Fig-submit-R1.pdf"},"version_id":"6d845318-89c2-4e4d-bc4f-9d61efde4b9c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"NF-kB decoy-submit-R1.pdf","filesize":[{"value":"192.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NF-kB decoy-submit-R1.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24210/files/NF-kB decoy-submit-R1.pdf"},"version_id":"dca8d66f-b6ee-484b-bdd3-84bdb9cdac90"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Iontophoresis","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-κB decoy","subitem_subject_scheme":"Other"},{"subitem_subject":"Oligonucleotides","subitem_subject_scheme":"Other"},{"subitem_subject":"Transdermal delivery","subitem_subject_scheme":"Other"},{"subitem_subject":"Skin inflammation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-22"},"publish_date":"2010-11-22","publish_status":"0","recid":"24210","relation_version_is_last":true,"title":["Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-08-01T09:22:18.567167+00:00"}