{"_buckets": {"deposit": "3df3f1eb-c6c2-4bad-ad4f-0a412e899741"}, "_deposit": {"created_by": 1, "id": "24333", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "24333"}, "status": "published"}, "_oai": {"id": "oai:kumadai.repo.nii.ac.jp:00024333", "sets": ["414"]}, "author_link": ["158242", "158241"], "item_15_alternative_title_22": {"attribute_name": "その他の言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Heme biosynthesis and lead anemia"}]}, "item_15_alternative_title_23": {"attribute_name": "タイトル（ヨミ）", "attribute_value_mlt": [{"subitem_alternative_title": "ヘム セイゴウセイ ト ナマリ ヒンケツ"}]}, "item_15_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-01-31", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "6", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "熊本大学医学部保健学科紀要"}]}]}, "item_15_creator_3": {"attribute_name": "別言語の著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Harada, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "158242", "nameIdentifierScheme": "WEKO"}]}]}, "item_15_description_17": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_15_description_46": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "論文(Article)", "subitem_description_type": "Other"}]}, "item_15_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "鉛貧血については、鉛により赤血球膜の浸透圧に対する脆弱性が増大し、そのため赤血球が破壊することによる溶血性貧血と、ヘム生合成への鉛の阻害作用による貧血の2つの観点から理解される。ここでは、ヘム生合成に影響する鉛による貧血について考察する。", "subitem_description_type": "Other"}, {"subitem_description": "The nature of lead anemia is still unknown about its mechanism. There are some hypotheses that lead interfere with specific enzymes such as 5-aminolevurinic acid dehydratase, ferrochelatase and reductase participating heme biosynthesis in bodies. It is thought that by the perturbation of lead on the heme pathway 5-aminolevulinic acid and protoporphyrin accumulate in urine and blood, respectively. It is also supposed that lead interfere with intake of iron into the site of heme biosynthesis. The determined values of porphyrins are not only good biological parameters for the effect of lead on heme biosynthesis but also well evaluating the supposed mechanism of lead anemia. The present paper well reviews the point of lead disturbance about heme biosynthesis.", "subitem_description_type": "Other"}]}, "item_15_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "熊本大学"}]}, "item_15_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "18807151", "subitem_source_identifier_type": "ISSN"}]}, "item_15_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12010572", "subitem_source_identifier_type": "NCID"}]}, "item_15_subject_20": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "493.152", "subitem_subject_scheme": "NDC"}]}, "item_15_text_18": {"attribute_name": "形態", "attribute_value_mlt": [{"subitem_text_value": "1074812 bytes"}]}, "item_15_text_47": {"attribute_name": "資源タイプ・ローカル", "attribute_value_mlt": [{"subitem_text_value": "紀要論文"}]}, "item_15_text_48": {"attribute_name": "資源タイプ・NII", "attribute_value_mlt": [{"subitem_text_value": "Departmental Bulletin Paper"}]}, "item_15_text_49": {"attribute_name": "資源タイプ・DCMI", "attribute_value_mlt": [{"subitem_text_value": "text"}]}, "item_15_text_50": {"attribute_name": "資源タイプ・ローカル表示コード", "attribute_value_mlt": [{"subitem_text_value": "02"}]}, "item_15_text_76": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_text_value": "http://hdl.handle.net/2298/17776"}]}, "item_15_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "原田, 幸一"}], "nameIdentifiers": [{"nameIdentifier": "158241", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "MH0002_001-006.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "MH0002_001-006.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/24333/files/MH0002_001-006.pdf"}, "version_id": "822e8eca-0f08-40ed-88b4-d3feb92ef75f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Lead anemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "heme biosynthesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "iron deficiency anemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protoporhyrin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "5-aminolevulinic acid", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ヘム生合成と鉛貧血", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ヘム生合成と鉛貧血"}]}, "item_type_id": "15", "owner": "1", "path": ["414", "1267"], "permalink_uri": "http://hdl.handle.net/2298/17776", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-01-27"}, "publish_date": "2011-01-27", "publish_status": "0", "recid": "24333", "relation": {}, "relation_version_is_last": true, "title": ["ヘム生合成と鉛貧血"], "weko_shared_id": -1}