{"created":"2023-06-19T09:12:33.823050+00:00","id":24417,"links":{},"metadata":{"_buckets":{"deposit":"88ca02f6-7731-4673-b289-55beca767a3f"},"_deposit":{"created_by":12,"id":"24417","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"24417"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024417","sets":["415:430"]},"author_link":["147106"],"item_18_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-14","bibliographicIssueDateType":"Issued"}}]},"item_18_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"がん抑制遺伝子産物であるp53タンパク質は、細胞のがん化を抑える重要な働きをしている。したがってp53の働きを増強する薬剤は、がんを治療できると考えられる。本研究では、p53-Hdm2複合体形成とUbc13-Uev1A複合体形成の阻害を指標として、海洋資源からp53の作用を増強させる低分子化合物の探索を行った。さらに、当研究室において既に確立したアッセイ系を用いて、広くユビキチン-プロテアソームシステムに対する阻害物質の探索を行った。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"p53 plays an important role on suppression of tumor, and the drugs which enhance the effect of p53 will treat a various cancer. In this study, we search for compounds, which inhibit the interactions of p53-Hdm2 and Ubc13-Uev1A from marine organisms.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499.1","subitem_subject_scheme":"NDC"}]},"item_18_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成19～21年度科学研究費補助金(基盤研究(B))研究成果報告書　課題番号：19310140"}]},"item_18_text_80":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_text_value":"19310140"}]},"item_18_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 佐知子","creatorNameLang":"ja"},{"creatorName":"ツカモト, サチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsukamoto, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"147106","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"KaB19310140.pdf","filesize":[{"value":"129.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KaB19310140.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24417/files/KaB19310140.pdf"},"version_id":"5e7a4038-236a-47be-b573-c1f94093e78b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ユビキチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテアソーム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"がん抑制遺伝子産物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗がん剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"天然低分子化合物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"海洋生物","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん抑制遺伝子産物の作用を増強させる天然低分子化合物の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん抑制遺伝子産物の作用を増強させる天然低分子化合物の開発","subitem_title_language":"ja"},{"subitem_title":"ガン ヨクセイ イデンシ サンブツ ノ サヨウ オ ゾウキョウ サセル テンネン テイブンシ カゴウブツ ノ カイハツ","subitem_title_language":"ja-Kana"},{"subitem_title":"Search for Natural Products Which Enhance the Effect of Tumor Suppressor Protein","subitem_title_language":"en"}]},"item_type_id":"18","owner":"12","path":["430"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-01-19"},"publish_date":"2011-01-19","publish_status":"0","recid":"24417","relation_version_is_last":true,"title":["がん抑制遺伝子産物の作用を増強させる天然低分子化合物の開発"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-05T04:08:33.547501+00:00"}