{"created":"2023-06-19T09:12:36.263081+00:00","id":24458,"links":{},"metadata":{"_buckets":{"deposit":"323e8e04-a7fe-4333-bb8c-b5f5c957c4a7"},"_deposit":{"created_by":1,"id":"24458","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24458"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024458","sets":["407:424:425"]},"author_link":["108815","108817","108816"],"item_18_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis on the mechanisms of regionalization and morphogenesis of the inner ear"}]},"item_18_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ナイジ ノ リョウイキカ オヨビ ケイタイ ケイセイ オ セイギョ スル イデンシ ノ ドウテイ ト キノウ カイセキ"}]},"item_18_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05-31","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_18_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Katsu, Kenjiro"}],"nameIdentifiers":[{"nameIdentifier":"108817","nameIdentifierScheme":"WEKO"}]}]},"item_18_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_18_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_18_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"我々は分泌性因子DAN がニワトリ胚の耳胞の背側に発現し、内リンパ管・嚢の形成を制御することを明らかにしてきた。耳胞の領域化には、耳胞背側のDlx5,Gbx2を介する経路と、耳胞腹側のOtx2を介する経路が関与すると考えられており、これらがDAN発現を制御する可能性がある。これを検証するため、Dlx5,Gbx2,Otx2を耳胞に導入し、DANの発現変動を検討した。その結果、Gbx2とOtx2がDANの発現を抑制することが判った。Gbx2とDAN の発現領域は重複するため、DAN発現の活性化にはGbx2の効果を打ち消す作用をもつ因子が必要であることが示唆された。","subitem_description_type":"Other"},{"subitem_description":"DAN, a secreted molecule of DAN/Cerberus family, is expressed in\nthe dorsal side of the otic vesicle of the chick embryo and regulates the formation of\nendolymphatic duct and sac. Otic vesicle is patterned by dorsal pathway through Dlx5 and\nGbx2, and ventral pathway through Otx2. These two pathways might regulate expression of\nDAN in the otic vesicle. To test this possibility, we introduced exogenous Dlx5, Gbx2,\nand Otx2 into the otic vesicle and assessed the expression of DAN. We found that both\nGbx2 and Otx2 suppressed DAN. These results suggest that activation of DAN expression\nrequires a factor that cancels the effect of Gbx2 since the area of Gbx2 and DAN expression\nis largely overlapped in the developing otic vesicles.","subitem_description_type":"Other"}]},"item_18_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.175","subitem_subject_scheme":"NDC"}]},"item_18_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"524006 bytes"}]},"item_18_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"研究報告書"}]},"item_18_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Research Paper"}]},"item_18_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_18_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"06"}]},"item_18_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成19～21年度科学研究費補助金(基盤研究(C))研究成果報告書　課題番号：19590174"}]},"item_18_text_80":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_text_value":"19590174"}]},"item_18_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝, 賢二郎"}],"nameIdentifiers":[{"nameIdentifier":"108815","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"KaC19590174.pdf","filesize":[{"value":"524.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KaC19590174.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24458/files/KaC19590174.pdf"},"version_id":"8f6e5dc5-1947-490e-8e39-2417cc937906"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"解剖学","subitem_subject_scheme":"Other"},{"subitem_subject":"内耳","subitem_subject_scheme":"Other"},{"subitem_subject":"内リンパ管・嚢","subitem_subject_scheme":"Other"},{"subitem_subject":"発生・分化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"内耳の領域化及び形態形成を制御する遺伝子の同定と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内耳の領域化及び形態形成を制御する遺伝子の同定と機能解析"}]},"item_type_id":"18","owner":"1","path":["425"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-28"},"publish_date":"2011-01-28","publish_status":"0","recid":"24458","relation_version_is_last":true,"title":["内耳の領域化及び形態形成を制御する遺伝子の同定と機能解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T18:24:14.783412+00:00"}