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Cell signaling mediated by nitrated cyclic guanine nucleotide
http://hdl.handle.net/2298/17931
http://hdl.handle.net/2298/17931392e3847-5730-47a8-879c-2ffb88a5c02a
| 名前 / ファイル | ライセンス | アクション |
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NOBC23_3_166-174.pdf (668.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-02-08 | |||||
| タイトル | ||||||
| タイトル | Cell signaling mediated by nitrated cyclic guanine nucleotide | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cell signaling, Nitric oxide, Nitrated cyclic nucleotide, 8-Nitro-cGMP, S-Guanylation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
赤池, 孝章
× 赤池, 孝章× 藤井, 重元× 澤, 智裕× 居原, 秀 |
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| 別言語の著者 |
赤池, 孝章
× 赤池, 孝章× 藤井, 重元× 澤, 智裕× 居原, 秀 |
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| 内容記述 | ||||||
| 内容記述 | We recently clarified the physiological formation of 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) and its critical roles in nitric oxide (NO) signal transductions. This discovery of 8-nitro-cGMP is the first demonstration of a nitrated cyclic nucleotide functioning as a new second messenger in mammals since the identification of cGMP more than 40. years ago. By means of chemical analyses, e.g., liquid chromatography-tandem mass spectrometry, we unequivocally identified 8-nitro-cGMP formation, which depended on NO production, in several types of cultured cells, including macrophages and glial cells. Most important, we previously showed that 8-nitro-cGMP as an electrophile reacted with particular sulfhydryls of proteins to generate a unique post-translational modification that we called protein S-guanylation. In fact, certain specific intracellular proteins, such as the redox-sensor protein Keap1, readily underwent S-guanylation induced by 8-nitro-cGMP. 8-Nitro-cGMP activated the Nrf2 signaling pathway by triggering dissociation of Keap1, via S-guanylation of its highly nucleophilic cysteine sulfhydryls. We also determined that S-guanylation of Keap1 was involved in cytoprotective actions of NO and 8-nitro-cGMP by inducing oxidative stress response genes such as heme oxygenase-1. Such unique chemical properties of 8-nitro-cGMP shed light on new areas of NO and cGMP signal transduction. Protein S-guanylation induced by 8-nitro-cGMP may thus have important implications in NO-related physiology and pathology, pharmaceutical chemistry, and development of therapeutics for many diseases. | |||||
| 書誌情報 |
Nitric Oxide - Biology and Chemistry 巻 23, 号 3, p. 166-174, 発行年 2010-11 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.niox.2010.06.006 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Elsevier Inc. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 10898603 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 668222 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 465 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNT-50CV846-1&_user=4545557&_coverDate=11%2F01%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=9e7e99db7729f8c21d50cffe81f352c2&searchtype=a | |||||
