{"created":"2023-06-19T09:12:39.674542+00:00","id":24525,"links":{},"metadata":{"_buckets":{"deposit":"c5390f42-8336-49e6-964e-f8409029e911"},"_deposit":{"created_by":1,"id":"24525","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24525"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024525","sets":["413:443"]},"author_link":["109315","109312","109313","109314","118920","92765","92770"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"174","bibliographicPageStart":"166","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Nitric Oxide - Biology and Chemistry"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤池, 孝章"}],"nameIdentifiers":[{"nameIdentifier":"109312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤井, 重元"}],"nameIdentifiers":[{"nameIdentifier":"109313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"澤, 智裕"}],"nameIdentifiers":[{"nameIdentifier":"109314","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Ihara, Hideshi","creatorNameLang":"en"},{"creatorName":"居原, 秀","creatorNameLang":"ja"},{"creatorName":"イハラ, ヒデシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ihara","familyNameLang":"en"},{"familyName":"居原","familyNameLang":"ja"},{"familyName":"イハラ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hideshi","givenNameLang":"en"},{"givenName":"秀","givenNameLang":"ja"},{"givenName":"ヒデシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"109315","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We recently clarified the physiological formation of 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) and its critical roles in nitric oxide (NO) signal transductions. This discovery of 8-nitro-cGMP is the first demonstration of a nitrated cyclic nucleotide functioning as a new second messenger in mammals since the identification of cGMP more than 40. years ago. By means of chemical analyses, e.g., liquid chromatography-tandem mass spectrometry, we unequivocally identified 8-nitro-cGMP formation, which depended on NO production, in several types of cultured cells, including macrophages and glial cells. Most important, we previously showed that 8-nitro-cGMP as an electrophile reacted with particular sulfhydryls of proteins to generate a unique post-translational modification that we called protein S-guanylation. In fact, certain specific intracellular proteins, such as the redox-sensor protein Keap1, readily underwent S-guanylation induced by 8-nitro-cGMP. 8-Nitro-cGMP activated the Nrf2 signaling pathway by triggering dissociation of Keap1, via S-guanylation of its highly nucleophilic cysteine sulfhydryls. We also determined that S-guanylation of Keap1 was involved in cytoprotective actions of NO and 8-nitro-cGMP by inducing oxidative stress response genes such as heme oxygenase-1. Such unique chemical properties of 8-nitro-cGMP shed light on new areas of NO and cGMP signal transduction. Protein S-guanylation induced by 8-nitro-cGMP may thus have important implications in NO-related physiology and pathology, pharmaceutical chemistry, and development of therapeutics for many diseases.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNT-50CV846-1&_user=4545557&_coverDate=11%2F01%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=9e7e99db7729f8c21d50cffe81f352c2&searchtype=a","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.niox.2010.06.006","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10898603"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 Elsevier Inc."}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"465","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"668222 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal 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