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Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow
http://hdl.handle.net/2298/20081
http://hdl.handle.net/2298/20081f5a3a8f0-be2f-4bd9-8480-c43b3e2ec9b3
| 名前 / ファイル | ライセンス | アクション |
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figures_AMN24_5_387-393.pdf (650.7 kB)
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ANM24_5_387-393.pdf (85.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-07-07 | |||||
| タイトル | ||||||
| タイトル | Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | CBF measurement, arterial input function, 123I-IMP, Pulmonary dynamic imaging | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
冨口, 静二
× 冨口, 静二× 田代, 城主× Shiraishi, Shinya× 吉田, 守克× Kawanaka, Koichi× Takahashi, Yoshitake× Soma, Tsutomu× 山下, 康行 |
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| 別言語の著者 |
冨口, 静二
× 冨口, 静二× 田代, 城主× 白石, 慎哉× 吉田, 守克× 河中, 功一× 山下, 康行 |
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| 内容記述 | ||||||
| 内容記述 | Purpose: I-123 labeled N-isopropyl-p-iodoamphetamine(123I-IMP) is used for measurement of regional cerebral blood flow(rCBF). A continuous or single arterial blood sampling(ABS) is necessary to estimate an integral of arterial input function(AIF) for the measurement of rCBF by using a microsphere model analysis. Therefore, the method to measure rCBF without any blood sampling is desired. The aim of this study was to establish the method to estimate the AIF from the time-activity curve of the lungs after the injection of 123I-IMP using a regression analysis for the measurement of rCBF without any blood sampling. Materials and methods: Thirty-seven prospective studies in 10 consecutive patients were enrolled. A chest planar dynamic imaging for 3 minutes and continuous ABS for 5 minutes after a bolus injection of 167MBq 123I-IMP were performed in all studies. Data from the chest imaging were analyzed in comparison with ABS data(AIF(5)) in the first 10 studies, and an equation for estimation yielding accurate AIF(5) from the total counts cleared from the lungs during 5 minutes after injection of 123I-IMP(TCL(5)) was derived. The validity of the proposed method was evaluated in the subsequent 27 studies. Results: A good correlation was obtained between the AIF and TCL by regression analysis in the first 10 studies(r=0.94, p<0.001). An equation for the estimation of AIF by the regression analysis in the first 10 studies was defined as follows, estimated AIF=2146.7336 +4.1735xTCL(5). In the subsequent 27 studies, a good linear correlation was obtained between measured AIF(5) and estimated AIF(5) by using the equation(r=0.79, p<0.001). Conclusion: AIF(5) can be accurately estimated from the TCL(5). Therefore, estimated AIF(5) can be used for the measurement of rCBF instead of ABS data. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 24, 号 5, p. 387-393, 発行年 2010-06 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20349161 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s12149-010-0370-1 | |||||
| 権利 | ||||||
| 権利情報 | ©The Japanese Society of Nuclear Medicine 2010 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 09147187 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 85839 bytes | ||||||
| 形態 | ||||||
| 650706 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 492 | |||||
| 出版者 | ||||||
| 出版者 | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE | |||||
| 別言語の出版者 | ||||||
| 日本核医学会 | ||||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/k26771x8021k18n7/ | |||||
| コメント | ||||||
| The original publication is available at www.springerlink.com | ||||||
