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Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis
http://hdl.handle.net/2298/18592
http://hdl.handle.net/2298/1859254413370-af0b-4b57-b509-73d9945e0e4a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Science_330_6011_1670-1673.pdf (4.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-04-21 | |||||
| タイトル | ||||||
| タイトル | Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Mochida, Satoru
× Mochida, Satoru× Maslen, Sarah L.× Skehel, Mark× Hunt, Tim |
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| 別言語の著者 |
持田, 悟
× 持田, 悟 |
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| 内容記述 | ||||||
| 内容記述 | Entry into mitosis in eukaryotes requires the activity of Cyclin-dependent kinase 1 (CDK1). CDK1 is opposed by protein phosphatases in two ways: they inhibit its activation by dephosphorylating the protein kinases Wee1 and Myt1 and the protein phosphatase Cdc25 (key regulators of Cdk1) and they also antagonize its own phosphorylation of downstream targets. A particular form of protein phosphatase 2A (PP2A) containing a B55δ subunit is the major protein phosphatase that acts on model CDK substrates in Xenopus egg extracts and has anti-mitotic activity. The activity of PP2A-B55δ is high in interphase and low in mitosis, exactly opposite to that of CDK1. We report that inhibition of PP2A-B55δ results from a small protein known as α-Endosulfine (Ensa), which is phosphorylated in mitosis by the protein kinase Greatwall (Gwl). This converts Ensa into a potent and specific inhibitor of PP2A-B55δ. This pathway represents a new element in the control of mitosis. |
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| 書誌情報 |
Science 巻 330, 号 6011, p. 1670-1673, 発行年 2010-12-17 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21164013 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1126/science.1195689 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00368075 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 4235637 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencemag.org/content/330/6011/1670 | |||||
