{"created":"2023-06-19T09:12:46.726817+00:00","id":24667,"links":{},"metadata":{"_buckets":{"deposit":"faf2ad4b-2235-48c9-b8a2-f82210058bd0"},"_deposit":{"created_by":1,"id":"24667","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24667"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024667","sets":["415:416"]},"author_link":["110186","110189","110206","110202","110203","110187","110192","110193","110204","118920","110201","110205","110207","92765","110188"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-09-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"127","bibliographicPageStart":"121","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Nitric Oxide"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"異島, 優"}],"nameIdentifiers":[{"nameIdentifier":"110201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"廣山, 秀一"}],"nameIdentifiers":[{"nameIdentifier":"110202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸山, 徹"}],"nameIdentifiers":[{"nameIdentifier":"110203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"澤, 智裕"}],"nameIdentifiers":[{"nameIdentifier":"110204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤池, 孝章"}],"nameIdentifiers":[{"nameIdentifier":"110205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甲斐, 俊哉"}],"nameIdentifiers":[{"nameIdentifier":"110206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小田切, 優樹"}],"nameIdentifiers":[{"nameIdentifier":"110207","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"S-Nitrosated human serum albumin (SNO-HSA) is a large molecular weight nitric oxide carrier in human plasma, and because of its many beneficial effects in different tests, it is currently under investigation as a cytoprotective agent. However, making SNO-HSA preparations is a complicated and time-consuming process. We found that binding of caprylic acid (CA) and N-acetyl-L-tryptophan (N-AcTrp) to defatted mercaptalbumin increased S-nitrosation by S-nitrosoglutathione (GS-NO) by making Cys-34 of HSA more accessible and by protecting it against oxidation, respectively. Fortunately, HSA solutions for clinical use contain high concentrations of CA and N-AcTrp as stabilizers. By making use of that fact it was possible to work-out a fast and simple procedure for producing SNO-HSA: Incubation of a commercial HSA formulation with GS-NO for only one minute results in S-nitrosation of HSA. The biological usefulness of such a preparation was tested in a rat ischemia-reperfusion liver injury model. Although our procedure for making SNO-HSA is fast and straightforward, the cytoprotective effect of the preparation was similar to, or better than, that of a preparation made in a more traditional way. The clinical development of SNO-HSA as a strong cytoprotective agent is under way using this method in collaboration with clinicians and industrial 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