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Olfactory bulb axonal outgrowth is inhibited by draxin
http://hdl.handle.net/2298/18898
http://hdl.handle.net/2298/188982815f450-cf91-498c-b681-6a81bb02e1b8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBRC_398_4_730-734.pdf (268.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-18 | |||||
| タイトル | ||||||
| タイトル | Olfactory bulb axonal outgrowth is inhibited by draxin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Draxin, olfactory bulb, axonal outgrowth, LOT, repulsive guidance cue | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ahmed, Giasuddin
× Ahmed, Giasuddin× 新明, 洋平× Bin Naser, Iftekhar× Hossain, Mahmud× Song, Xiaohong× 田中, 英明 |
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| 別言語の著者 |
新明, 洋平
× 新明, 洋平× 田中, 英明 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Olfactory bulb (OB) projection neurons receive sensory input from olfactory receptor neurons and precisely relay it through their axons to the olfactory cortex. Thus, olfactory bulb axonal tracts play an important role in relaying information to the higher order of olfactory structures in the brain. Several classes of axon guidance molecules influence the pathfinding of the olfactory bulb axons. Draxin, a recently identified novel class of repulsive axon guidance protein, is essential for the formation of forebrain commissures and can mediate repulsion of diverse classes of neurons from chickens and mice. In this study, we have investigated the draxin expression pattern in the mouse telencephalon and its guidance functions for OB axonal projection to the telencephalon. We have found that draxin is expressed in the neocortex and septum at E13 and E17.5 when OB projection neurons form the lateral olfactory tract (LOT) rostrocaudally along the ventrolateral side of the telencephalon. Draxin inhibits axonal outgrowth from olfactory bulb explants in vitro and draxin-binding activity in the LOT axons in vivo is detected. The LOT develops normally in draxin-/- mice despite subtle defasciculation in the tract of these mutants. These results suggest that draxin functions as an inhibitory guidance cue for OB axons and indicate its contribution to the formation of the LOT. |
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| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 398, 号 4, p. 730-734, 発行年 2010-08 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20621059 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.bbrc.2010.07.010 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Elsevier Inc | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 0006291X | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 268447 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-50GWN4B-9&_user=4545557&_coverDate=08%2F06%2F2010&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=87745a4d2f6a736af1b4c44fc56b88f5&searchtype=a | |||||
