@article{oai:kumadai.repo.nii.ac.jp:00024713,
 author = {川浦, 一晃 and 三木, 理沙 and 浦嶋, 優里 and 本田, 宗吉 and 副田, 二三夫 and 白崎, 哲哉 and 高濱, 和夫 and 川浦, 一晃 and Kawaura, Kazuaki and 三木, 理沙 and Miki, Risa and Urashima, Yuri and 本田, 宗吉 and Honda, Sokichi and M. Shehata, Ahmed and 副田, 二三夫 and Soeda, Fumio and 白崎, 哲哉 and Shirasaki, Tetsuya and 高濱, 和夫 and Takahama, Kazuo},
 issue = {1-3},
 journal = {European Journal of Pharmacology},
 month = {Jan},
 note = {application/pdf, application/pdf, 論文(Article), Several antidepressants have been used to treat severe pain in clinics. Recently, we
reported that the centrally acting non-narcotic antitussive (cough suppressant drug),
tipepidine produces an antidepressant-like effect in the forced swimming test, although
the mechanism of action appears to be quite different from that of known
antidepressants. In the present study, we investigated whether a combination of
tipepidine and carbamazepine acts synergistically to induce an antinociceptive effect in
the acetic acid-induced writhing test in mice. Prior to studying the combination of
tipepidine and carbamazepine, the analgesic action of tipepidine alone was also
examined in mice. Tipepidine at 5–40 mg/kg i.p. significantly reduced the number of
writhes induced by acetic acid in mice. Carbamazepine at 20 mg/kg i.p. also
significantly reduced the writhing reaction. Furthermore, co-administration of
carbamazepine (5 and 10 mg/kg, i.p.) and tipepidine (2.5 mg/kg i.p.) significantly
decreased the number of writhes induced by acetic acid. This finding suggests that a
combination of carbamazepine and tipepidine may be a new strategy for the treatment
of neuropathic pain such as what occurs in trigeminal neuralgia, because the use of
carbamazepine is often limited by its adverse effects and by reduction of its analgesic
efficacy by microsomal enzyme induction., http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-51JXFP1-S&_user=4545557&_coverDate=01%2F25%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=8b9435572e26660fc145da2e40e62499&searchtype=a},
 pages = {106--108},
 title = {Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test},
 volume = {651},
 year = {2011},
 yomi = {カワウラ, カズアキ and ミキ, リサ and ホンダ, ソウキチ and ソエダ, フミオ and シラサキ, テツヤ and タカハマ, カズオ}
}