{"created":"2023-06-19T09:12:48.798146+00:00","id":24713,"links":{},"metadata":{"_buckets":{"deposit":"736616a1-7bc8-4adf-87fc-ef296db4c3e4"},"_deposit":{"created_by":1,"id":"24713","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24713"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024713","sets":["415:416"]},"author_link":["110728","110714","107925","110730","110685","110726","110731","119256","110712","110727","110729","110725","110683","110687","125184"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"108","bibliographicPageStart":"106","bibliographicVolumeNumber":"651","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川浦, 一晃"}],"nameIdentifiers":[{"nameIdentifier":"110725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木, 理沙"}],"nameIdentifiers":[{"nameIdentifier":"110726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浦嶋, 優里"}],"nameIdentifiers":[{"nameIdentifier":"110727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本田, 宗吉"}],"nameIdentifiers":[{"nameIdentifier":"110728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"副田, 二三夫"}],"nameIdentifiers":[{"nameIdentifier":"110729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白崎, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"110730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高濱, 和夫"}],"nameIdentifiers":[{"nameIdentifier":"110731","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Several antidepressants have been used to treat severe pain in clinics. Recently, we\nreported that the centrally acting non-narcotic antitussive (cough suppressant drug),\ntipepidine produces an antidepressant-like effect in the forced swimming test, although\nthe mechanism of action appears to be quite different from that of known\nantidepressants. In the present study, we investigated whether a combination of\ntipepidine and carbamazepine acts synergistically to induce an antinociceptive effect in\nthe acetic acid-induced writhing test in mice. Prior to studying the combination of\ntipepidine and carbamazepine, the analgesic action of tipepidine alone was also\nexamined in mice. Tipepidine at 5–40 mg/kg i.p. significantly reduced the number of\nwrithes induced by acetic acid in mice. Carbamazepine at 20 mg/kg i.p. also\nsignificantly reduced the writhing reaction. Furthermore, co-administration of\ncarbamazepine (5 and 10 mg/kg, i.p.) and tipepidine (2.5 mg/kg i.p.) significantly\ndecreased the number of writhes induced by acetic acid. This finding suggests that a\ncombination of carbamazepine and tipepidine may be a new strategy for the treatment\nof neuropathic pain such as what occurs in trigeminal neuralgia, because the use of\ncarbamazepine is often limited by its adverse effects and by reduction of its analgesic\nefficacy by microsomal enzyme induction.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-51JXFP1-S&_user=4545557&_coverDate=01%2F25%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=8b9435572e26660fc145da2e40e62499&searchtype=a","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_16_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21114989","subitem_relation_type_select":"PMID"}}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejphar.2010.10.086","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"00142999"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 Elsevier B.V."}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"178791 bytes"},{"subitem_text_value":"27713 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