{"created":"2023-06-19T09:12:48.985068+00:00","id":24717,"links":{},"metadata":{"_buckets":{"deposit":"1f606402-ef75-4f31-b9b5-6038f1528e61"},"_deposit":{"created_by":1,"id":"24717","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24717"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024717","sets":["415:416"]},"author_link":["110758","110748","110759","110749","110746","110757","110760","110747","110756","94310"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-09-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"307","bibliographicPageStart":"298","bibliographicVolumeNumber":"170","bibliographic_titles":[{"bibliographic_title":"Neuroscience"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小袋, 加奈絵"}],"nameIdentifiers":[{"nameIdentifier":"110756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"瀧川, 萌子"}],"nameIdentifiers":[{"nameIdentifier":"110757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久恒, 昭哲"}],"nameIdentifiers":[{"nameIdentifier":"110758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"礒濱, 洋一郎"}],"nameIdentifiers":[{"nameIdentifier":"110759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"香月, 博志"}],"nameIdentifiers":[{"nameIdentifier":"110760","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Orexins are neuropeptides produced in the lateral hypothalamus and implicated in regulation of sleep-wake cycle.  Selective loss of orexin neurons is found in the brain of patients with narcolepsy, but the mechanisms of this pathological change are unclear.  A previous study showed that excessive stimulation of N-methyl-D-aspartate (NMDA) receptors by quinolinic acid (QA) caused selective loss of orexin neurons in rat hypothalamic slice culture.  Here we examined QA toxicity on orexin neurons and melanin-concentrating hormone (MCH) neurons in vivo.  Contrary to the expectation, injection of QA (60 and 120 nmol) into the lateral hypothalamus of male C57BL/6 mice caused selective loss of MCH neurons rather than orexin neurons, and this toxicity of QA was attenuated by MK-801, an NMDA receptor antagonist.  Selective loss of MCH neurons with preserved orexin neurons was observed even when GABAA receptor antagonists such as bicuculline and picrotoxin were injected with QA.  A significant decrease in the number of orexin neurons was induced when QA injection was performed in the dark phase of diurnal cycle, but the degree of the decrease was still lower than that in the number of MCH neurons.  Finally, QA (60 nmol) induced selective loss of MCH neurons also in young rats at 3 - 4 weeks of age.  These results do not support the hypothesis that acute excitotoxicity mediated by NMDA receptors is responsible for the pathogenesis of narcolepsy.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.scopus.com/record/display.url?eid=2-s2.0-77955920655&origin=resultslist&sort=plf-f&src=s&st1=QUINOLINATE+INDUCES+SELECTIVE+LOSS&sid=f-qhVPJ2u2Lk21TXA-UeNmo%3a90&sot=b&sdt=b&sl=49&s=TITLE-ABS-KEY%28QUINOLINATE+INDUCES+SELECTIVE+LOSS%29&relpos=0&relpos=0&searchTerm=TITLE-ABS-KEY%28QUINOLINATE%20INDUCES%20SELECTIVE%20LOSS%29","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuroscience.2010.06.081","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"03064522"}]}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2010 IBRO. Published by Elsevier Ltd"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.17","subitem_subject_scheme":"NDC"},{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"135103 bytes"},{"subitem_text_value":"3225402 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Obukuro, Kanae"}],"nameIdentifiers":[{"nameIdentifier":"110746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takigawa, Moeko"}],"nameIdentifiers":[{"nameIdentifier":"110747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisatsune, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"110748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isohama, Yoichiro"}],"nameIdentifiers":[{"nameIdentifier":"110749","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"香月, 博志","creatorNameLang":"ja"},{"creatorName":"カツキ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Katsuki, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"香月","familyNameLang":"ja"},{"familyName":"カツキ","familyNameLang":"ja-Kana"},{"familyName":"Katsuki","familyNameLang":"en"}],"givenNames":[{"givenName":"博志","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94310","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"リバイス-r.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"リバイス-r.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24717/files/リバイス-r.pdf"},"version_id":"0a906df3-002a-433a-b469-72fed29a5421"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"NS_170_1_298-307.pdf","filesize":[{"value":"135.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NS_170_1_298-307.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24717/files/NS_170_1_298-307.pdf"},"version_id":"990b6ac6-b24c-4568-9d82-a3ece6880ba9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"excitotoxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"hypocretin","subitem_subject_scheme":"Other"},{"subitem_subject":"narcolepsy","subitem_subject_scheme":"Other"},{"subitem_subject":"quinolinic acid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-23"},"publish_date":"2011-05-23","publish_status":"0","recid":"24717","relation_version_is_last":true,"title":["Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-30T05:48:53.100190+00:00"}