@article{oai:kumadai.repo.nii.ac.jp:00024726,
 author = {小原　恭子 and 笠間, 由里 and 関口, 敏 and 齊藤, 誠 and 田中, 康介 and Tanaka, Kohsuke and 佐藤, 正明 and 桑原, 一彦 and 阪口, 薫雄 and 竹屋, 元裕 and 日浅, 陽一 and 小原, 道法 and 小原, 恭子 and Kohara, Kyoko and 笠間, 由里 and Kasama, Yuri and Sekiguchi, Satoshi and Saito, Makoto and 田中, 康介 and Tanaka, Kohsuke and Satoh, Masaaki and Kuwahara, Kazuhiko and 阪口, 薫雄 and Sakaguchi, Nobuo and 竹屋, 元裕 and Takeya, Motohiro and Hiasa, Yoichi and Kohara, Michinori and 小原, 恭子 and Kohara, Kyoko and Tsukiyama-Kohara, Kyoko},
 issue = {23},
 journal = {Blood},
 month = {Dec},
 note = {application/pdf, 論文(Article), Extrahepatic manifestations of hepatitis C virus (HCV) infection have been
reported in 40–70% of HCV-infected patients. B-cell non-Hodgkin’s lymphoma is a
typical extrahepatic manifestation frequently associated with HCV infection. Although
the HCV infection of B cells has been reported, the mechanism of disease onset remains
unclear. In this study we established HCV transgenic mice that express the full HCV
genome in B cells (RzCD19Cre mice) and observed a 25.0% incidence of non-Hodgkin’s
diffuse large B-cell lymphomas (22.2% in males and 25.9% in females) within 600 days
after birth. Expression levels of aspartate aminotransferase, alanine aminotransferase,
and 32 different cytokines, chemokines and growth factors were examined. The
incidence of B-cell lymphoma was significantly correlated with only the level of soluble
interleukin-2 receptor ! subunit (sIL-2R!) in RzCD19Cre mouse serum. All
RzCD19Cre mice with substantially elevated serum sIL-2Rα levels (>1,000 pg/mL)
developed B-cell lymphomas. Moreover, compared to tissues from control animals, the
B-cell lymphoma tissues of RzCD19Cre mice expressed significantly higher levels of
IL-2Rα. We show that the expression of HCV in B cells promotes non-Hodgkin’s-type
diffuse B-cell lymphoma, and therefore, the RzCD19Cre mouse is a powerful model to
study the mechanisms related to the development of HCV-associated B-cell lymphoma., http://bloodjournal.hematologylibrary.org/content/116/23/4926},
 pages = {4926--4933},
 title = {Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo.},
 volume = {116},
 year = {2010},
 yomi = {タナカ, コウスケ and コハラ, キョウコ and カサマ, ユリ and タナカ, コウスケ and サカグチ, ノブオ and タケヤ, モトヒロ and コハラ, キョウコ}
}