{"created":"2023-06-19T09:12:49.386325+00:00","id":24726,"links":{},"metadata":{"_buckets":{"deposit":"60ef9d92-391f-4d37-be14-f7c177313b9e"},"_deposit":{"created_by":1,"id":"24726","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24726"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024726","sets":["413:443"]},"author_link":["110832","110833","165839","110858","110852","120682","110829","110853","110857","110851","93151","110855","110854","120675","110859","110836","110850","110830","110837","110856","110860"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageEnd":"4933","bibliographicPageStart":"4926","bibliographicVolumeNumber":"116","bibliographic_titles":[{"bibliographic_title":"Blood"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小原　恭子"}],"nameIdentifiers":[{"nameIdentifier":"110850","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠間, 由里"}],"nameIdentifiers":[{"nameIdentifier":"110851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関口, 敏"}],"nameIdentifiers":[{"nameIdentifier":"110852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齊藤, 誠"}],"nameIdentifiers":[{"nameIdentifier":"110853","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"田中, 康介","creatorNameLang":"ja"},{"creatorName":"タナカ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Tanaka, Kohsuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"田中","familyNameLang":"ja"},{"familyName":"タナカ","familyNameLang":"ja-Kana"},{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"康介","givenNameLang":"ja"},{"givenName":"コウスケ","givenNameLang":"ja-Kana"},{"givenName":"Kohsuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 正明"}],"nameIdentifiers":[{"nameIdentifier":"110855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桑原, 一彦"}],"nameIdentifiers":[{"nameIdentifier":"110856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阪口, 薫雄"}],"nameIdentifiers":[{"nameIdentifier":"110857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹屋, 元裕"}],"nameIdentifiers":[{"nameIdentifier":"110858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"日浅, 陽一"}],"nameIdentifiers":[{"nameIdentifier":"110859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小原, 道法"}],"nameIdentifiers":[{"nameIdentifier":"110860","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Extrahepatic manifestations of hepatitis C virus (HCV) infection have been\nreported in 40–70% of HCV-infected patients. B-cell non-Hodgkin’s lymphoma is a\ntypical extrahepatic manifestation frequently associated with HCV infection. Although\nthe HCV infection of B cells has been reported, the mechanism of disease onset remains\nunclear. In this study we established HCV transgenic mice that express the full HCV\ngenome in B cells (RzCD19Cre mice) and observed a 25.0% incidence of non-Hodgkin’s\ndiffuse large B-cell lymphomas (22.2% in males and 25.9% in females) within 600 days\nafter birth. Expression levels of aspartate aminotransferase, alanine aminotransferase,\nand 32 different cytokines, chemokines and growth factors were examined. The\nincidence of B-cell lymphoma was significantly correlated with only the level of soluble\ninterleukin-2 receptor ! subunit (sIL-2R!) in RzCD19Cre mouse serum. All\nRzCD19Cre mice with substantially elevated serum sIL-2Rα levels (>1,000 pg/mL)\ndeveloped B-cell lymphomas. Moreover, compared to tissues from control animals, the\nB-cell lymphoma tissues of RzCD19Cre mice expressed significantly higher levels of\nIL-2Rα. We show that the expression of HCV in B cells promotes non-Hodgkin’s-type\ndiffuse B-cell lymphoma, and therefore, the RzCD19Cre mouse is a powerful model to\nstudy the mechanisms related to the development of HCV-associated B-cell lymphoma.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://bloodjournal.hematologylibrary.org/content/116/23/4926","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society of Hematology"}]},"item_16_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"20733156","subitem_relation_type_select":"PMID"}}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1182/blood-2010-05-283358","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"00064971"}]}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.87","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"3153425 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vivo."}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-27"},"publish_date":"2011-05-27","publish_status":"0","recid":"24726","relation_version_is_last":true,"title":["Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-26T04:44:49.303648+00:00"}