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アイテム
Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.
http://hdl.handle.net/2298/19079
http://hdl.handle.net/2298/1907981222e8f-6da0-4cb2-9bd4-cb37dbdf40d7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JMV_83_5_801.pdf (5.3 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-03-11 | |||||
| タイトル | ||||||
| タイトル | Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Apoptosis, Hepatitis C virus, Non-structural protein 3, Translocase of outer mitochondrial membrane 70, Tumor necrosis factor-alpha | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takashi, Takano
× Takashi, Takano× Michinori ,Kohara× Yuri, Kasama× 西村, 知裕× Makoto, Saito× Chieko, Kai× Kyoko, Tsukiyama-Kohara |
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| 別言語の著者 |
小原, 恭子
× 小原, 恭子× 高野, 貴士× 小原, 道法× 笠間, 由里× 西村, 知裕× 齊藤, 誠× 甲斐, 知恵子 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The localization of hepatitis C virus (HCV) proteins in cells leads to several problems. The translocase of outer mitochondrial membrane 70 (TOM70) is a mitochondrial import receptor. In this study, TOM70 expression was induced by HCV infection. TOM70 overexpression induced resistance to tumor necrosis factor-alpha (TNF-α)-mediated apoptosis but not to Fas-induced apoptosis in HepG2 cells. TOM70 was found to be induced by the HCV non-structural protein (NS)3/4A protein, and silencing of TOM70 decreased the levels of the NS3 and Mcl-1 proteins. These results indicate that TOM70 can directly interact with the NS3 protein. In hepatoma cells, silencing of TOM70 induced apoptosis and increased caspase-3/7 activity but did not modify caspase-8 and caspase-9 activity. TOM70 silencing-induced apoptosis was impaired in HCV NS3/4A protein-expressing cells. Thus, this study revealed a novel finding, that is, TOM70 is linked with the NS3 protein and the apoptotic response. | |||||
| 書誌情報 |
Journal of Medical Virology 巻 83, 号 5, p. 801-809, 発行年 2011-05 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1002/jmv.22046 | |||||
| 権利 | ||||||
| 権利情報 | © 2011 Wiley-Liss, Inc. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 01466615 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 5324084 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.8 | |||||
| 出版者 | ||||||
| 出版者 | Wiley-Liss, Inc. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://onlinelibrary.wiley.com/doi/10.1002/jmv.22046/abstract | |||||
| コメント | ||||||
| 値 | "This is the peer reviewed version of the following article: [http://onlinelibrary.wiley.com/doi/10.1002/jmv.22046/abstract], which has been published in final form at [http://dx.doi.org/10.1002/jmv.22046]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." | |||||
