@article{oai:kumadai.repo.nii.ac.jp:00024732,
 author = {尾田, 済太郎 and 粟井, 和夫 and 船間, 芳憲 and 宇都宮, 大輔 and 彌永, 由美 and 河中, 功一 and 中浦, 猛 and 平井, 俊範 and 村上, 龍次 and 野守, 裕明 and 山下, 康行 and Oda, Seitaro and Awai, Kazuo and Funama, Yoshinori and 宇都宮, 大輔 and Utsunomiya, Daisuke and Yanaga, Yumi and Kawanaka, Koichi and 中浦, 猛 and Nakaura, Takeshi and Hirai, Toshinori and 村上, 龍次 and Murakami, Ryuji and Nomori, Hiroaki and 山下, 康行 and Yamashita, Yasuyuki},
 issue = {8},
 journal = {Clinical Radiology},
 month = {Aug},
 note = {application/pdf, 論文(Article), AIM:We investigated the effect of a double-exposure dual-energy subtraction (DES) technique on the performance of radiologists detecting small pulmonary nodules on flat-panel detector (FPD) chest radiographs.
MATERIALS AND METHODS:Using FPD radiography we obtained 41 sets of chest radiographs from 26 patients with pulmonary nodules measuring ≤ 20 mm and from 15 normal subjects.  Each data set included standard- and corresponding DES images.  There were 6 non-solid-, 10 part-solid-, and 10 solid nodules.  The mean size of the 26 nodules was 15.0 ± 4.8 mm.  We performed receiver operating characteristic (ROC) analysis to compare the performance of 8 board-certified radiologists.
RESULTS:For the 8 radiologists, the mean value of the area under the ROC curve (AUC) without and with DES images was 0.62 ± 0.05 and 0.68 ± 0.05, respectively; the difference was statistically significant (p = 0.02).  For part-solid nodules, the difference of the mean AUC value was statistically significant (AUC = 0.61 ± 0.07 vs. 0.69 ± 0.05; p < 0.01); for non-solid nodules it was not (AUC = 0.62 ± 0.10 vs. 0.61 ± 0.09; p = 0.73), and for solid nodules it was not (AUC = 0.75 ± 0.10 vs. 0.78 ± 0.08; p = 0.23).  For nodules with overlapping bone shadows, the difference of the mean AUC value was statistically significant (p = 0.03), for nodules without overlapping, it was not (p = 0.26).
CONCLUSION:Use of a double-exposure DES technique at FPD chest radiography significantly improved the diagnostic performance of radiologists detecting small pulmonary nodules., http://www.sciencedirect.com/science/article/pii/S0009926010001170},
 pages = {609--615},
 title = {Detection of small pulmonary nodules on chest radiographs: efficacy of dual-energy subtraction technique using flat-panel detector chest radiography},
 volume = {65},
 year = {2010},
 yomi = {ウツノミヤ, ダイスケ and ナカウラ, タケシ and ムラカミ, リュウジ and ヤマシタ, ヤスユキ}
}