{"created":"2023-06-19T09:12:51.379350+00:00","id":24769,"links":{},"metadata":{"_buckets":{"deposit":"1b4df170-4d2d-4165-837e-da65b9ca54cc"},"_deposit":{"created_by":1,"id":"24769","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"24769"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00024769","sets":["413:429"]},"author_link":["111361","93163"],"item_18_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular and genetic basis of congenital insensitivity to pain"}]},"item_18_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"センテンセイ ムツウショウ ノ ブンシ イデンガク テキ キバン"}]},"item_18_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-04-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_18_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Indo, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"111361","nameIdentifierScheme":"WEKO"}]}]},"item_18_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf"}]},"item_18_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_18_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"先天性無痛無汗症(CIPA)は温覚・痛覚と発汗機能を欠如し、精神遅滞を伴う常染色体劣性遺伝の疾患である。私たちは、1996年にこの疾患の原因をはじめて明らかにし、報告した。CIPAの原因は、神経成長因子(NGF)に対する受容体タンパク質をコードする遺伝子TRKA(NTRK1)の機能喪失性変異である。本研究では、CIPAの分子病態を解析することにより、NGFが内感覚神経と交感神経の両者の生存・維持に必須であることを示唆する結果を得た。このことは、疼痛のメカニズムを考える上で、新たな視点を開く可能性がある。","subitem_description_type":"Other"}]},"item_18_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.37","subitem_subject_scheme":"NDC"}]},"item_18_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"27766 bytes"}]},"item_18_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"研究報告書"}]},"item_18_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Research Paper"}]},"item_18_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_18_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"06"}]},"item_18_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成18～20年度科学研究費補助金(基盤研究(C))研究成果報告書　課題番号：18613012"}]},"item_18_text_80":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_text_value":"18613012"}]},"item_18_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Indo, Yasuhiro","creatorNameLang":"en"},{"creatorName":"犬童, 康弘","creatorNameLang":"ja"},{"creatorName":"インドウ, ヤスヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Indo","familyNameLang":"en"},{"familyName":"犬童","familyNameLang":"ja"},{"familyName":"インドウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"},{"givenName":"康弘","givenNameLang":"ja"},{"givenName":"ヤスヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"93163","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"KaC18613012.pdf","filesize":[{"value":"27.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KaC18613012.pdf","url":"https://kumadai.repo.nii.ac.jp/record/24769/files/KaC18613012.pdf"},"version_id":"a5a29a2c-e44d-4ed9-bf1f-f362654162d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"先天性無痛症","subitem_subject_scheme":"Other"},{"subitem_subject":"先天性無痛無汗症","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性感覚自律神経性ニューパチーIV型","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ型受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"先天性無痛症の分子遺伝学的基盤","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"先天性無痛症の分子遺伝学的基盤"}]},"item_type_id":"18","owner":"1","path":["429"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-08"},"publish_date":"2011-06-08","publish_status":"0","recid":"24769","relation_version_is_last":true,"title":["先天性無痛症の分子遺伝学的基盤"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-24T02:46:21.645968+00:00"}